Publications by authors named "Christopher J Melani"
Proc Natl Acad Sci U S A
December 2024
Article Synopsis
- Clinical trials for cancer treatments should be based on strong scientific understanding and proven drug effectiveness in relevant disease models.
- This study examines the effects of four small-molecule drugs on lymphoma cell lines, revealing that synergistic combinations effectively induce cell death (apoptosis) in a way that mimics actual drug exposure in patients.
- The findings suggest that in vitro drug screening can help identify effective drug combinations that leverage their synergistic effects to tackle the complexity of human cancers, especially in diverse genetic lymphoma models.
