Publications by authors named "Christopher I Milton"
Article Synopsis
- HSP90 is a molecular chaperone that stabilizes proteins linked to cancer, with its inhibitors disrupting various cellular protein networks and signaling pathways.
- A study used size-exclusion chromatography and mass spectrometry to examine how the HSP90 inhibitor tanespimycin affects protein complexes in colon cancer cells over 8 hours.
- Findings showed only slight changes in protein distributions but identified new modulated proteins, which may provide valuable insights for cancer research and understanding protein stabilization processes.
Rhabdomyosarcomas are aggressive pediatric soft-tissue sarcomas and include high-risk PAX3-FOXO1 fusion-gene-positive cases. Fibroblast growth factor receptor 4 (FGFR4) is known to contribute to rhabdomyosarcoma progression; here, we sought to investigate the involvement and potential for therapeutic targeting of other FGFRs in this disease. Cell-based screening of FGFR inhibitors with potential for clinical repurposing (NVP-BGJ398, nintedanib, dovitinib, and ponatinib) revealed greater sensitivity of fusion-gene-positive versus fusion-gene-negative rhabdomyosarcoma cell lines and was shown to be correlated with high expression of FGFR2 and its specific ligand, FGF7.
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