Publications by authors named "Christopher Hensel"
Article Synopsis
- The study investigates whether statins, known for their anti-inflammatory properties, can reduce markers of HIV persistence and inflammation in individuals on long-term antiretroviral therapy (ART).
- Researchers compared levels of specific HIV-related markers and immune activation between 303 statin users and non-users, finding no significant differences except for a slight variation in the IP-10 marker.
- The conclusions suggest that statins do not significantly lower HIV persistence or immune activation in this cohort, indicating more research is necessary to determine their potential impact.
Data on the relationship of antiretroviral exposure to measures of human immunodeficiency virus (HIV) persistence are limited. To address this gap, multiple viral, immunologic, and pharmacologic measures were analyzed from individuals with sustained virologic suppression on therapy (median 7 years) in the AIDS Clinical Trials Group A5321 cohort. Among 110 participants on tenofovir-(TFV)-disoproxil-fumarate (TDF)/emtricitabine (FTC)-containing regimens, we found no significant correlation between hair concentrations of individual antiretrovirals (ARVs) in the regimen and measures of HIV persistence (plasma HIV-1 RNA by single copy assay, cell-associated-DNA, cell-associated RNA) or soluble markers of inflammation.
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