Publications by authors named "Christopher Gottschalk"
Background: We aimed to assess the effects of preventive migraine treatment with atogepant vs. placebo on patient-reported quality of life and functioning.
Methods: Analyses of patient-reported outcomes from three 12-week, randomized, placebo-controlled trials evaluating preventive migraine treatment with atogepant 60 mg once-daily: ADVANCE (low-frequency episodic migraine [LFEM], 4-8 monthly migraine days [MMDs] and high-frequency episodic migraine [HFEM], 8-14 MMDs), PROGRESS (chronic migraine, CM) and ELEVATE (episodic migraine in those previously failed by two to four classes of oral preventive treatments).
Article Synopsis
Article Synopsis
- - Migraines are complex headaches accompanied by various neurological symptoms, but their underlying causes are still poorly understood.
- - The research by Nelson-Maney and colleagues reveals that CGRP (Calcitonin Gene-Related Peptide) plays a crucial role in how meningeal lymphatic vessels (MLVs) function during migraines, affecting the movement of cerebrospinal fluid (CSF).
- - Blocking CGRP signaling in MLVs reduced migraine-related pain in rodents, suggesting potential new treatments for primary headache disorders targeting CGRP.
Article Synopsis
- * Researchers built phylogenetic trees based on genomic data to confirm previous studies and analyzed gene clusters related to pathogenicity, identifying similarities and variations among species.
- * The findings aim to identify potential targets for new control strategies, utilizing advanced omics technologies to understand the biological reasons for the pathogens' success in specific geographic regions.
Article Synopsis
Article Synopsis
- * A study analyzed the genomes of 290 TN patients and found an increase in harmful genetic variants linked to GABA receptor-binding genes, suggesting a disruption in pain signaling.
- * Additional findings also pointed to rare mutations in sodium and calcium channels, indicating that issues with ion transport might contribute to TN symptoms.