Publications by authors named "Christopher Gordon McKennan"
Front Neurosci
November 2023
Article Synopsis
- Late-onset Alzheimer's disease (LOAD) significantly impacts seniors, causing issues like memory loss and confusion, with Apolipoprotein-E (ApoE) recognized as a key risk factor for the condition.
- The study hypothesizes that ApoE’s effects on LOAD risk might originate from changes in brain network architecture during neurodevelopment.
- Using diffusion tensor imaging (DTI) and graph theory, researchers found that ApoE knockout mice exhibited distinct differences in brain connectivity compared to wild-type mice, suggesting ApoE plays a crucial role in how brain networks develop, which could influence vulnerability to LOAD.
