Hurricane wind regimes for forests of North America.

Despite the ubiquity of tropical cyclones and their impacts on forests, little is known about how tropical cyclone regimes shape the ecology and evolution of tree species. We used a simple meteorological model (HURRECON) to estimate wind fields from hurricanes in the Western North Atlantic and Eastern North Pacific tropical cyclone basins from storms occurring between 1851 and 2022. We characterize how the intensity and frequency of hurricanes differ among geographically distinct hurricane regimes and define four hurricane regimes for North America (Continental, Inland, Coastal, and Fringe).

The UT health Psychological Autopsy Interview Schedule (UTH- PAIS) - Description and reliability of diagnoses and transdiagnostic personality measures.

Few studies have used psychological autopsies to evaluate large and diverse populations on transdiagnostically relevant variables such as personality, temperament, and trauma exposure; rather, they tend to focus on specific psychiatric disorders or manner of death. We therefore developed the UT Health Psychological Autopsy Interview Schedule (UTH-PAIS). The measure is described, and our results show that the PAIS diagnoses and dimensions can be reliably assessed.

Infects Glial Cells and Invades the Central Nervous System the Olfactory and Trigeminal Nerves.

causes neonatal meningitis and can also infect the adult central nervous system (CNS). can cross the blood-brain barrier but may also reach the CNS other paths. Several species of bacteria can directly invade the CNS the olfactory and trigeminal nerves, which extend between the nasal cavity and brain and injury to the nasal epithelium can increase the risk/severity of infection.

Therapy Fears and Help-Seeking Behaviors among Mothers: Examining Racial Differences in Mental Health Services.

In the United States, approximately 20% of children and adolescents meet diagnostic criteria for a mental health diagnosis, but few receive treatment. The purpose of the current study was to explore the factors that contribute to help-seeking among mothers from diverse ethnic groups (52.5% European American/White, 23% African American/Black, and 24.

Investigating the influence of contributing factors and predicting visibility at road link-level.

Data from weather stations at airports, far away locations or predictions using macro-level data may not be accurate enough to disseminate visibility related information to motorists in advance. Therefore, the objective of this research is to investigate the influence of contributing factors and develop visibility prediction models, at road link-level, by considering data from weather stations located within 1.6 km of state routes, US routes and interstates in the state of North Carolina (NC).

Correction to: Mosquito-borne heartworm Dirofilaria immitis in dogs from Australia.

Since publication of the original version of this article [1], it has been flagged that unfortunately there is an error in dosage units in the Discussion section, in the sentence "For example a microfilaricide, either ivermectin (50-200 mg/kg) or milbemycin oxime (500-1,000 mg/kg)".

Mosquito-borne heartworm Dirofilaria immitis in dogs from Australia.

Background: Heartworm (Dirofilaria immitis) in dogs is considered endemic in Australia, but the clinical heartworm disease caused by the heartworm is rare and prevalence is low. The mainstream prevention of the heartworm is based on macrocyclic lactone (ML) administration. The aim of this study was to confirm endemism of the heartworm under current Australian conditions using a cohort of recent microfilaria-positive dogs which were on variable heartworm prevention.

The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.

Extensive molecular modeling based on crystallographic data was used to aid the design of synthetic analogues of the fungicidal naturally occurring respiration inhibitors crocacins A and D, and an inhibitor binding model to the mammalian cytochrome bc(1) complex was constructed. Simplified analogues were made which showed high activity in a mitochondrial beef heart respiration assay, and which were also active against certain plant pathogens in glasshouse tests. A crystal structure was obtained of an analogue of crocacin D bound to the chicken heart cytochrome bc(1) complex, which validated the binding model and which confirmed that the crocacins are a new class of inhibitor of the cytochrome bc(1) complex.

Who wins in the status games? Violence, sexual violence, and an emerging single standard among adolescent women.

Throughout U.S. history, women have changed their sexual behaviors in response to, or as actors affecting, economic, political, and legal imperatives; to preserve health; to promote new relationship, identity or career paths; to assert a set of values; as a result of new reproductive technologies; or to gain status.

Hugging my uncle: the impact of a parent training on children's comfort interacting with persons living with HIV.

Objective: HIV-related stigma affects not only persons living with HIV (PLwHIV) but also their communities and families including children. This study aimed to determine whether an interactive training administered to community parents significantly increases their children's reported comfort interacting with PLwHIV.

Methods: A randomized clinical trial with random-quota dwelling unit sampling and a random invitation to treatment had 238 parent and 238 child participants.

A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

The inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) by fosmidomycin was studied by using a kinetic assay based on the consumption of NADPH and synthetic substrate. Fosmidomycin is a slow tight-binding inhibitor of DXR that shows strong negative cooperativity (absolute value(h) = 0.3) in binding.

Data supplementation: a pharmacokinetic/pharmacodynamic knowledge creation approach for characterizing an unexplored region of the response surface.

Purpose: To develop a data supplementation [i.e., a pharmacokinetic/pharmacodynamics (PK/PD) knowledge creation] approach for generating supplemental data to be used in characterizing a targeted unexplored segment of the response surface.

Rapid and flexible synthesis of 1-deoxy-D-xylulose-5-phosphate, the substrate for 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

1-Deoxy-D-xylulose-5-phosphate (DXP) is a key intermediate in the non-mevalonate pathway to terpenoids in bacteria, and it is the substrate for the enzyme 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXP-R). In order to study the mechanism of DXP-R, we required a flexible synthesis of the substrate which would allow the incorporation of isotopic labels, and the variation of the two stereocentres. Thus 1,4-dihydroxypent-2-yne was selectively reduced to give the E-olefin, and selective phosphorylation of the primary alcohol followed by oxidation of the secondary alcohol gave a substrate suitable for dihydroxylation.