Publications by authors named "Christopher G O'Neill"
JCI Insight
December 2024
Article Synopsis
- Cutaneous wounds heal slowly and often result in scarring, whereas oral wounds heal more rapidly due to differences in cellular responses in the skin and oral epithelium.
- The transcription factor PITX1 is abundant in oral epithelial cells but absent in skin cells, and researchers wanted to see if introducing PITX1 into skin cells could improve healing.
- By inserting PITX1 in mouse skin, they found it enhanced keratinocyte migration and proliferation, changed cell communication to resemble oral tissue, and resulted in faster healing compared to normal skin.
