Publications by Christopher G Larminie

Publications by authors named "Christopher G Larminie"

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Cloning and pharmacological characterisation of the guinea pig 5-ht5A receptor.

David R Thomas Christopher G Larminie Helen R Lyons Andrew Fosberry Matthew J Hill

Eur J Pharmacol

June 2004

The guinea pig 5-hydroxytryptamine(5A) (gp5-ht(5A)) receptor was cloned from guinea pig brain using degenerate polymerase chain reaction (PCR) and shows 88%, 85% and 84% amino acid sequence identity versus the human, rat and mouse 5-ht(5A) receptors, respectively. The receptor was transiently expressed in human embryonic kidney (HEK) 293 cells. [(3)H]-Lysergic acid diethylamide (LSD) bound saturably to gp5-ht(5A)/HEK293 membranes with a K(d) of 2.

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