Publications by authors named "Christopher Differ"
Article Synopsis
- - The study explores the relationship between bone morphogenetic protein 2 (BMP2) and nitric oxide (NO) signaling, noting that while BMP2 is beneficial for bone repair, it can also have negative side effects and cost issues due to high application doses.
- - Researchers used C2C12BRELuc cells to assess how NO donors and inhibitors affect BMP signaling, finding that NO enhances BMP2's signaling and osteogenic effects, suggesting a potential way to use lower doses of BMP2 effectively.
- - The findings indicate that the NO pathway boosts BMP2 signaling via protein kinase A (PKA), reinforcing the potential of combining treatments to optimize bone healing while minimizing negative impacts.
Article Synopsis
- - The study explores how bone morphogenetic protein 7 (BMP-7) can potentially minimize tendon re-tears post-surgery by enhancing tenogenic characteristics in human tenocyte-like cells (hTLCs).
- - BMP-7 activates specific signaling pathways including Smad1/5/8 and p38, leading to increased expression of crucial genes linked to tendon repair, while having minimal effect on pathways associated with bone and cartilage formation.
- - Findings suggest that targeting BMP-7 signaling may improve outcomes in rotator cuff repair by promoting the production of tendon-related markers like scleraxis and collagen I, without encouraging unwanted bone or cartilage development.
Maintaining potassium (K(+) ) nutrition and a robust guard cell K(+) inward channel activity is considered critical for plants' adaptation to fluctuating and challenging growth environment. ABA induces stomatal closure through hydrogen peroxide and nitric oxide (NO) along with subsequent ion channel-mediated loss of K(+) and anions. However, the interactions of NO synthesis and signalling with K(+) nutrition and guard cell K(+) channel activities have not been fully explored in Arabidopsis.
View Article and Find Full Text PDFArticle Synopsis
- Receptor tyrosine kinases (RTKs) are important cell surface receptors that help cells respond to growth factors and hormones, influencing cell behavior in both healthy and diseased states.
- Researchers developed a novel type of RTKs that can be activated specifically by low-intensity blue light, bypassing the need for traditional ligands.
- This new method, called Opto-RTKs, allows scientists to precisely control and study cellular signaling and behavior at specific times and locations, showing potential for applications in cancer research and therapies.