Publications by authors named "Christopher Dajadian"
LARP1 is a key repressor of TOP mRNA translation. It binds the m7Gppp cap moiety and the adjacent 5'TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F complex on these transcripts. mTORC1 controls TOP mRNA translation via LARP1, but the details of the mechanism are unclear.
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- The mTORC1 complex plays a crucial role in regulating protein synthesis, particularly affecting the translation of specific mRNAs identified as TOP and TOP-like mRNAs.
- This study identifies La-related protein 1 (LARP1) as a significant target of mTORC1 that acts as a repressor for the translation of these TOP mRNAs.
- LARP1 interacts with mTORC1 and TOP mRNAs, competing with other initiation factors, and its reduction can lead to decreased inhibitory effects of drugs like rapamycin on TOP mRNA translation.