Publications by authors named "Christopher D Tran"
Article Synopsis
- The integral membrane enzyme PagP helps E. coli evade immune responses by transferring a palmitoyl group from a phospholipid to lipid A.
- PagP features an internal hydrocarbon ruler within its β barrel structure, which measures the palmitoyl group during the transfer.
- Studies using molecular dynamics and crystal structure analysis reveal that the phospholipid enters PagP through a specific gap, allowing the head group to stay outside while the hydrophobic tail moves into the protein.
