Anatomically guided reconstruction improves lesion quantitation and detectability in bone SPECT/CT.

Bone single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging suffers from poor spatial resolution, but the image quality can be improved during SPECT reconstruction by using anatomical information derived from CT imaging. The purpose of this work was to compare two different anatomically guided SPECT reconstruction methods to ordered subsets expectation maximization (OSEM) which is the most commonly used reconstruction method in nuclear medicine. The comparison was done in terms of lesion quantitation and lesion detectability.

Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study.

Our objective was to use rapid dynamic SPECT to study the effect of hygroscopic growth on aerosol deposition in the lung. Six healthy volunteers inhaled radiolabeled ((99m)Tc-DTPA) saline aerosols of two different droplet sizes (MMAD Small 3.2 +/- 0.