Publications by authors named "Christopher C Kuhn"
Article Synopsis
- - The study focuses on the relationship between mRNA translation and decay in human cells, specifically highlighting the role of the cytoplasmic exosome in degrading mRNA linked to ribosomes during quality control.
- - Researchers identified that HBS1L3 (SKI7) facilitates a direct physical coupling between EXO10 and the ribosome-bound SKI238 complex, enabling efficient mRNA handover for degradation.
- - They discovered that the decay process involves a supercomplex formed by the exosome and ribosome, allowing mRNA to be efficiently threaded from the ribosome through the helicase to the exoribonuclease, effectively coordinating the decay mechanism.
Cryogenic electron microscopy (cryo-EM) and electron tomography (cryo-ET) have become a critical tool for studying viral particles. Cryo-EM has enhanced our understanding of viral assembly and replication processes at a molecular resolution. Meanwhile, cryo-ET has been used to investigate how viruses attach to and invade host cells.
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- SARS-CoV-2, the virus causing COVID-19, affects the body by interacting with host-cell receptors via its spike protein (S protein).
- The study reveals that the S protein triggers significant changes in platelets, which can lead to their permanent activation, a factor contributing to coagulopathies in COVID-19 patients.
- Researchers found that the S protein binds to specific platelet integrins that induce filopodia formation, suggesting that these interactions play a role in the disease's severity and blood clotting complications.
Article Synopsis
- SARS-CoV-2, the virus causing COVID-19, interacts with host-cell receptors through its spike protein, which is crucial for its high pathogenicity.
- The study reveals that the spike protein can cause platelets to deform and activate irreversibly, suggesting a direct link between the virus and coagulopathies in COVID-19 patients.
- Researchers found that the spike protein binds to specific integrin receptors on platelets, indicating that this interaction may play a role in the severe coagulation issues associated with COVID-19.