Publications by authors named "Christopher C Karayiannis"
Background: Type 2 diabetes (T2D) is associated with an increased risk of dementia and early features may become evident even in mid-life. Characterizing these early features comprehensively requires multiple measurement modalities and careful selection of participants with and without T2D.
Objective: We conducted a cross-sectional multimodal imaging study of T2D-discordant twins in late mid-life to provide insights into underlying mechanisms.
Article Synopsis
- Visible perivascular spaces (BGPVS) are linked to cerebral small vessel disease and may signal higher future stroke risk based on a large analysis of patient data.
- The study analyzed 7,778 participants with recent ischemic stroke or transient ischemic attack (TIA), examining the relationship between BGPVS, CSOPVS, and various health factors.
- Results indicated that a greater burden of BGPVS correlates with higher risks of ischemic stroke but not intracranial hemorrhage, while CSOPVS showed weaker associations overall.
Article Synopsis
- Researchers studied patients with certain types of strokes (IS or TIA) to find out how a brain condition called cortical superficial siderosis (cSS) affects their risk of having more strokes in the future.
- They looked at data from a large group of patients and found that those with cSS had a higher chance of having more strokes than those without it.
- Patients with cSS who took both types of blood-thinning medicines had an even higher risk of severe strokes and intracranial hemorrhage (bleeding in the brain).
Older patients with hypertension are at a higher risk of cardiovascular events compared to younger adults but are also more vulnerable to the adverse effects of blood pressure (BP) lowering. Frailty is an important predictor of vulnerability to such adverse events, and age alone may not best reflect underlying risk. Therefore, an individualised approach to management of hypertension in the older person is required.
View Article and Find Full Text PDFBackground We investigated whether blood pressure lowering for secondary prevention is associated with a reduction in recurrent stroke risk and/or a higher risk of adverse events in very elderly compared with younger trial participants. Methods and Results This is a random effects meta-analysis of randomized controlled trials of blood pressure lowering for secondary stroke prevention to evaluate age-stratified (<80, ≥80 years) risk of adverse events. Ovid-MEDLINE was searched for trials between 1970 and 2020.
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