Publications by authors named "Christopher Batho"
Immunotherapy harnesses neoantigens encoded within the human genome, but their therapeutic potential is hampered by low expression, which may be controlled by the nonsense-mediated mRNA decay (NMD) pathway. This study investigates the impact of UPF1-knockdown on the expression of non-canonical/mutant proteins, employing proteogenomic to explore UPF1 role within the NMD pathway. Additionally, we conducted a comprehensive pan-cancer analysis of UPF1 expression and evaluated UPF1 expression in Triple-Negative Breast Cancer (TNBC) tissue in-vivo.
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- - Vascular cells in human cardiac organoids (hCOs) significantly improve heart cell maturity, contraction strength, and their usefulness for studying diseases.
- - The study developed an optimized method to create different types of heart-related cells that organize into structures similar to those found in living organisms, revealing how these cells communicate and support each other.
- - Key findings include the roles of endothelial-derived LAMA5 and PDGFRβ signaling in enhancing heart contractility and suggesting that vascular cells influence the heart's response to inflammation and diastolic dysfunction.
Purpose Of Review: This review summarizes the important role that metabolism plays in driving maturation of human pluripotent stem cell-derived cardiomyocytes.
Recent Findings: Human pluripotent stem cell-derived cardiomyocytes provide a model system for human cardiac biology. However, these models have been unable to fully recapitulate the maturity observed in the adult heart.