Impact of PM filter extraction solvent on oxidative potential and chemical analysis.

Fine particulate matter (PM) is hypothesized to induce oxidative stress, and has been linked to acute and chronic adverse health effects. To better understand the risks and underlying mechanisms following exposure, PM is collected onto filters but prior to toxicological analysis, particles must be removed from filters. There is no standard method for filter extraction, which creates the possibility that the methods of extraction selected can alter the chemical composition and ultimately the biological implications.