Neurofilament light chain as a potential biomarker of disease status in Friedreich ataxia.

Background: The present study evaluates serum neurofilament light chain (NfL) as a biomarker of disease features in Friedreich's ataxia (FRDA).

Methods: NfL levels from serum of 117 subjects (85 FRDA patients, 13 carriers, and 19 controls) were assayed and correlated with disease features such as smaller GAA repeat length (GAA1), age, sex, and level of neurological dysfunction.

Results: Mean serum NfL levels were higher in FRDA patients than in carriers or unaffected controls in two independent cohorts of subjects.

Cross-study homogeneity of psoriasis gene expression in skin across a large expression range.

Background: In psoriasis, only limited overlap between sets of genes identified as differentially expressed (psoriatic lesional vs. psoriatic non-lesional) was found using statistical and fold-change cut-offs. To provide a framework for utilizing prior psoriasis data sets we sought to understand the consistency of those sets.