Publications by authors named "Christopher B Douville"
Article Synopsis
- - The study investigates the role of genetics in postoperative nausea and vomiting (PONV), which impacts patient satisfaction and results in unplanned hospital admissions after surgery, hypothesizing that genetic factors might explain some of the variability in risk that traditional factors do not cover.
- - Researchers conducted a genome-wide association study using data from patients at Michigan Medicine and Vanderbilt University Medical Center, identifying 46 genetic variants associated with PONV and developing a polygenic risk score to better predict occurrences in different patient cohorts.
- - Findings showed that higher polygenic risk scores corresponded with increased risk for developing PONV, suggesting that genetic predisposition combined with known clinical risks can improve understanding and prediction of this complication in surgical patients.
Background: Patients with coronavirus disease 2019 (COVID-19) requiring mechanical ventilation have high mortality and resource utilisation. The ability to predict which patients may require mechanical ventilation allows increased acuity of care and targeted interventions to potentially mitigate deterioration.
Methods: We included hospitalised patients with COVID-19 in this single-centre retrospective observational study.
Background: Existing genetic information can be leveraged to identify patients with susceptibilities to conditions that might impact their perioperative care, but clinicians generally have limited exposure and are not trained to contextualise this information. We identified patients with genetic susceptibilities to anaesthetic complications using a perioperative biorepository and characterised the concordance with existing diagnoses.
Methods: Adult patients undergoing surgery within Michigan Medicine from 2012 to 2017 were consented for genotyping.
Background: While postoperative myocardial injury remains a major driver of morbidity and mortality, the ability to accurately identify patients at risk remains limited despite decades of clinical research. The role of genetic information in predicting myocardial injury after noncardiac surgery (MINS) remains unknown and requires large scale electronic health record and genomic data sets.
Methods: In this retrospective observational study of adult patients undergoing noncardiac surgery, we defined MINS as new troponin elevation within 30 days following surgery.