Publications by authors named "Christopher A Rudyk"
Article Synopsis
- Parkinson's disease leads to a loss of dopamine-producing neurons, and current treatments mainly alleviate motor symptoms without significant neurorecovery.
- In a study, the mGluR5-negative allosteric modulator CTEP was tested in a mouse model for its effects on motor deficits and neural recovery.
- Results showed that CTEP improved motor function and promoted neural recovery, potentially by activating the mTOR pathway, suggesting that targeting this pathway could enhance neuroplasticity in Parkinson's disease patients.
Profiling changes in cortical astroglial cells following chronic stress.
Neuropsychopharmacology
August 2018
Recent studies have suggested that cortical astroglia play an important role in depressive-like behaviors. Potential astroglial contributions have been proposed based on their known neuroplastic functions, such as glutamate recycling and synaptic plasticity. However, the specific mechanisms by which astroglial cells may contribute or protect against a depressive phenotype remain unknown.
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