The increasing presence of emerging pollutants (EPs) in water poses significant environmental and health risks, necessitating effective treatment solutions. Originating from industrial, agricultural, and domestic sources, these contaminants threaten ecological and public health, underscoring the urgent need for innovative and efficient treatment methods. TiO-based semiconductor photocatalysts have emerged as a promising approach for the degradation of EPs, leveraging their unique band structures and heterojunction schemes.
View Article and Find Full Text PDFThe ongoing discussion regarding the use of mixed or pure cultures of hydrogenotrophic methanogenic archaea in Power-to-Methane (P2M) bioprocess applications persists, with each option presenting its own advantages and disadvantages. To address this issue, a comparison of methane (CH) yield between a novel methanogenic archaeon belonging to the species Methanothermobacter marburgensis (strain Clermont) isolated from a biological methanation column, and the community from which it originated, was conducted. This comparison included the type strain M.
View Article and Find Full Text PDFBackground: Myasthenia gravis (MG) is an autoimmune disease treated with acetylcholinesterase inhibitors and immunosuppressant/immunomodulatory drugs. MG is frequently diagnosed in elderly patients, a fragile population in which treatment adverse effects (TAE) have not been evaluated until now.
Methods: We retrospectively analysed the files of all MG patients with disease onset after age 70 years in four French University Hospitals, including clinical, electrophysiological, biological, and treatment data, with an emphasis on TAE.
Heterogeneous photocatalysis has been increasingly investigated during the past years and has been recognized as a promising technique for clean and safe water purification. The current study exploits the advantage of this technique demonstrating that the removal of a biorefractory water pollutant named clofibric acid can be really improved by photocatalysis through a parametric comprehensive investigation and optimization study based on response surface methodology. Its novelty comes from the approach used to enhance the efficiency of the photocatalytic degradation of clofibric acid.
View Article and Find Full Text PDFOil-in-water emulsions (20%/80%, w/w) were stabilised by two types of β-caseins (1 g/L, w/w) extracted by rennet coagulation from camel and cow's milk, respectively. Both extracts were treated under different ranges of pH (3.0, 6.
View Article and Find Full Text PDFThe design, modeling and simulation of an integrated biorefinery plant assumed to convert different forestry assortments such as sawdust or shavings (sawmill waste) into bioethanol from cellulose and hemicellulose as the main product, and lignin as the most valuable co-product, was carried out. The proposed lignocellulosic ethanol biorefinery plant was simulated with ProSimPlus. The model was based on experimental results and includes an Organosolv pretreatment, enzymatic hydrolysis, fermentation and distillation to obtain bioethanol.
View Article and Find Full Text PDFThe use of waste and by-products locally available in large quantities and at low cost as adsorbents can be considered an appropriate approach for improving waste management and protecting the environment. Cotton textile waste was used to prepare adsorbents (MC) via pyrolysis followed by a chemical modification with H PO . MC samples were characterized by scanning electron microscopy, FTIR spectroscopy, and N adsorption-desorption isotherm.
View Article and Find Full Text PDFThe aim of this work was to demonstrate the feasibility of second-generation bioethanol production using for the first time a sawmill mixed feedstock comprising four softwood species, representative of biomass resource in Auvergne-Rhône-Alpes region (France). The feedstock was subjected to a microwave-assisted water/ethanol Organosolv pretreatment. The investigation focused on enzymatic hydrolysis of this pretreated sawmill feedstock (PSF) using Cellic® Ctec2 as the enzyme, followed by fermentation of the resulting sugar solution using Saccharomyces cerevisiae strain.
View Article and Find Full Text PDFBackground: Kennedy's disease (KD), also known as spinal and bulbar muscular atrophy (SBMA), is a rare, adult-onset, X-linked recessive neuromuscular disease caused by CAG expansions in exon 1 of the androgen receptor gene (AR). The objective of the French national diagnostic and management protocol is to provide evidence-based best practice recommendations and outline an optimised care pathway for patients with KD, based on a systematic literature review and consensus multidisciplinary observations.
Results: The initial evaluation, confirmation of the diagnosis, and management should ideally take place in a tertiary referral centre for motor neuron diseases, and involve an experienced multidisciplinary team of neurologists, endocrinologists, cardiologists and allied healthcare professionals.
Camel α-lactalbumin (Ala-C), the main whey protein of camel milk, was purified by membrane filtration. Surface hydrophobicity as well as interfacial tension were examined at different levels of pH (3.0, 6.
View Article and Find Full Text PDFObjective: C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS). The aim of the present study was to determine whether C9ORF72-associated ALS (C9-ALS) patients present distinctive electrophysiological characteristics that could differentiate them from non C9ORF72-associated ALS (nonC9-ALS) patients.
Methods: Clinical and electrodiagnostic data from C9-ALS patients and nonC9-ALS patients were collected retrospectively.
The valorization of a solid carob waste from the Lebanese industry was investigated by optimizing the production of lactic acid using immobilized Lactobacillus rhamnosus in alginate beads and response surface methodology. The results showed that pH and alginate concentration had a significant effect on the production of lactic acid. The fermentation of non-enriched carob waste juice needed an additional nitrogen source to improve lactic acid production and yield.
View Article and Find Full Text PDFMyoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O facilitates its intracellular transport and serves as a controller of nitric oxide and reactive oxygen species. Here, we identify a recurrent c.
View Article and Find Full Text PDFA mixture of sawmill feedstocks comprising four softwood species (fir, spruce, Scots pine, and Douglas fir) was subjected to a microwave-assisted Organosolv pretreatment. The influence of HSO as a catalyst, ethanol-water ratio as the solvent, and temperature on wood fractionation, cellulose yield and purity, lignin recovery, and inhibitor formation were investigated. Minute addition of HSO (0.
View Article and Find Full Text PDFSodium channel myotonia and paramyotonia congenita are caused by gain-of-function mutations in the skeletal muscle voltage-gated sodium channel hNav1.4. The first-line drug is the sodium channel blocker mexiletine; however, some patients show side effects or limited responses.
View Article and Find Full Text PDFBackground: Off state toe dystonia (TD) is a symptom frequently encountered in Parkinson's disease (PD), but little is known about its evolution after subthalamic nucleus deep brain stimulation (STN-DBS).
Objective: To analyze the prevalence and the evolution of TD in PD patients candidate to STN-DBS.
Methods: Individual data of consecutive 130 PD patients who underwent STN-DBS between 2010 and 2015 were collected.
J Neuromuscul Dis
November 2018
Background: In Myotonic Dystrophy type 1 (DM1) patients, ankle muscles are affected early and this impairment is reported to be a good biological marker for longitudinal studies.
Objective: To characterize the ankle dorsiflexion (DF) and eversion (EV) maximal isometric muscle strength changes in adult DM1 patients over 5 years using a standardized handheld dynamometer protocol and the Myoankle method, compare the changes measured with both methods and to the standard error of measurement, and verify the relationship between ankle muscle strength and gait performance.
Methods: The maximal isometric muscle strength of ankle DF and EV in DM1 patients from Quebec and Lyon was assessed at baseline, 18, 36 and 60 months using a handheld dynamometer (HHD) protocol and the MyoAnkle method.
Objective: Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the gene, which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: alacrima, achalasia and adrenal insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported.
View Article and Find Full Text PDFParkinsonism Relat Disord
January 2018
J Neurol Neurosurg Psychiatry
May 2018
Objective: To assess the clinicopathological and therapeutic features of patients with low (≥1000 to <10 000 Bühlmann Titre Units) (BTU), medium (10 000-70 000) or high (≥70 000) anti-myelin-associated glycoprotein (anti-MAG) antibody titres.
Methods: We retrospectively and prospectively analysed standardised report forms and medical records of 202 patients from 14 neuromuscular centres.
Results: Mean age at onset and mean time between symptom onset to last follow-up were respectively 62.
Plantago notata (Plantaginaceae) is a spontaneous plant from Septentrional Algerian Sahara currently used by traditional healers to treat stomach disorders, inflammations or wound healing. A water-soluble polysaccharide, called PSPN (PolySaccharide fraction from Plantago Notata), was extracted and purified from the seeds of this semi-arid plant. The structural features of this mucilage were evaluated by colorimetric assays, Fourier transformed infrared spectroscopy (FT-IR), gas chromatography coupled to mass spectrometry (GC/MS) and H/C Nuclear Magnetic Resonance (NMR) spectroscopy.
View Article and Find Full Text PDFUnlabelled: An original stochastic finite element method (SFEM) is proposed for the texture analysis of food products for which samples cannot be standardized. SFEM is able to distinguish shape and texture variability. As an illustration, the methodology is applied to dry cat food using compression testing.
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