Publications by authors named "Christophe Thuaire"
Background: The appropriate duration of treatment with beta-blocker drugs after a myocardial infarction is unknown. Data are needed on the safety and efficacy of the interruption of long-term beta-blocker treatment to reduce side effects and improve quality of life in patients with a history of uncomplicated myocardial infarction.
Methods: In a multicenter, open label, randomized, noninferiority trial conducted at 49 sites in France, we randomly assigned patients with a history of myocardial infarction, in a 1:1 ratio, to interruption or continuation of beta-blocker treatment.
Background: Despite major advances in prevention and treatment, cardiovascular diseases - particularly acute myocardial infarction - remain a leading cause of death worldwide and in France. Collecting contemporary data about the characteristics, management and outcomes of patients with acute myocardial infarction in France is important.
Aims: The main objectives are to describe baseline characteristics, contemporary management, in-hospital and long-term outcomes of patients with acute myocardial infarction hospitalized in tertiary care centres in France; secondary objectives are to investigate determinants of prognosis (including periodontal disease and sleep-disordered breathing), to identify gaps between evidence-based recommendations and management and to assess medical care costs for the index hospitalization and during the follow-up period.
Tricuspid annular plane systolic excursion over systolic pulmonary artery pressure prognostic value for in-hospital adverse events in patients hospitalized for acute coronary syndrome.
Eur Heart J Cardiovasc Imaging
August 2024
Article Synopsis
- The study investigated the prognostic value of the TAPSE/sPAP ratio in patients hospitalized for acute coronary syndrome (ACS), focusing on its link to in-hospital major adverse cardiovascular events (MACEs).
- In a cohort of 481 patients, a TAPSE/sPAP ratio below 0.55 was found to significantly predict the occurrence of MACEs, with odds ratios indicating a very strong association even after accounting for other health factors.
- The findings highlight that a lower TAPSE/sPAP ratio improves risk assessment beyond conventional factors, suggesting it could serve as a critical marker for patient prognosis during hospitalization for ACS.
Article Synopsis
- Intensive cardiac care units (ICCU) in France have diversified from monitoring arrhythmias post-heart attack to treating various cardiac conditions, with acute coronary syndromes (ACS) being the most common cause for admission.
- A study of 1499 patients revealed that many have additional health concerns, with a significant portion requiring advanced therapies but a majority not needing invasive procedures.
- Overall, patients tend to have brief hospital stays with a low rate of major adverse events, although acute heart failure (AHF) patients face higher risks and resource use.
Prevalence of psychoactive drug use in patients hospitalized for acute cardiac events: Rationale and design of the ADDICT-ICCU trial, from the Emergency and Acute Cardiovascular Care Working Group and the National College of Cardiologists in Training of the French Society of Cardiology.
Arch Cardiovasc Dis
October 2022
Article Synopsis
- A study is being conducted to investigate the prevalence of psychoactive drug use in patients admitted to intensive cardiac care units for acute cardiovascular events across 39 centers in France.
- Researchers will systematically test patients for illicit and non-illicit psychoactive drugs using urine assays within 2 hours of admission, alongside assessing smoking and alcohol consumption.
- The study aims to explore the relationship between detected psychoactive drugs and in-hospital major adverse events, as well as track patient outcomes over a 12-month follow-up period.
Article Synopsis
- The study examines how to predict left main coronary artery disease (LMD) using clinical and stress testing parameters, noting its importance for patient outcomes.
- A total of 5,146 participants were analyzed, and it was found that older age, male sex, and certain stress test results could indicate LMD, but these predictions were not very strong.
- The authors conclude that for patients with moderate to severe ischemia, noninvasive imaging is crucial to accurately diagnose LMD, as clinical assessments alone are insufficient.
Introduction: We report the Case of a 35 years old male patient admitted for pulmonary embolism in a febrile context. Transthoracic echocardiography showed a filamentary mass appended to the pulmonary valve whose thrombotic origin has been suggested on data of late gadolinium enhancement magnetic resonance imaging.
Case Presentation: The patient had a history of deep vein thrombosis in the context of familial thrombophilia with factor V leiden gene mutation in two of his sisters and an inhaled drug addiction to heroïn.
Background: The COVID-19 pandemic has had a profound effect on general health care. We aimed to evaluate the effect of a nationwide lockdown in France on admissions to hospital for acute myocardial infarction, by patient characteristics and regional prevalence of the pandemic.
Methods: In this registry study, we collected data from 21 centres participating in the ongoing French Cohort of Myocardial Infarction Evaluation (FRENCHIE) registry, which collects data from all patients admitted for ST segment elevation myocardial infarction (STEMI) or non-ST segment elevation myocardial infarction (NSTEMI) within 48 h of symptom onset.
Background: Dual antiplatelet therapy, comprising aspirin and clopidogrel, is recommended in patients undergoing coronary stenting to avoid the occurrence of stent thrombosis and others ischaemic events. Interindividual response to clopidogrel varies, however, with poor response associated with an increased risk of ischaemic events. New assays are available for testing aspirin and clopidogrel response routinely at the bedside.
View Article and Find Full Text PDFInfarct artery distribution and clinical outcomes in occluded artery trial subjects presenting with non-ST-segment elevation myocardial infarction (from the long-term follow-up of Occluded Artery Trial [OAT]).
Am J Cardiol
April 2013
We hypothesized that the insensitivity of the electrocardiogram in identifying acute circumflex occlusion would result in differences in the distribution of the infarct-related artery (IRA) between patients with non-ST-segment elevation myocardial infarction (NSTEMI) and STEMI enrolled in the Occluded Artery Trial. We also sought to evaluate the effect of percutaneous coronary intervention to the IRA on the clinical outcomes for patients with NSTEMI. Overall, those with NSTEMI constituted 13% (n = 283) of the trial population.
View Article and Find Full Text PDFAim: To determine whether late recanalization of an occluded infarct artery after acute myocardial infarction is beneficial.
Methods And Results: Two hundred and twelve patients with a first Q-wave myocardial infarction (MI) and an occluded infarct vessel were enrolled. After coronary and left ventricular contrast angiography, patients were randomized to percutaneous revascularization (PTCA, n=109), carried out 2-15 days after symptom onset or medical therapy (n=103).