Publications by authors named "Christophe Rault"
Background: Poor sleep is a major concern in intensive care units (ICUs), particularly in mechanically ventilated patients, because it is associated with longer duration of the weaning phase and higher mortality. High noise levels in ICUs are frequently reported by patients as one of the most disturbing sleep-disrupting factors but would be responsible for less than 20% of arousals. This suggests major inter-individual variability in noise sensitivity.
View Article and Find Full Text PDFPurpose: Sleep deprivation (SD) reduces time to task failure during endurance exercises. The aim of our work was to study the effect of acute SD on the endurance of a skeletal hand muscle and to investigate cortical motor drive to muscle and perception of effort.
Methods: Origin of the early exhaustion after SD might be insufficient cortical motor drive to muscle or motor inhibition because of excessive perception of effort.
Article Synopsis
- Sleep deprivation is prevalent in ICUs and can negatively impact respiratory performance, yet its effects on critically ill patients' outcomes are not well-studied.
- The study analyzed sleep patterns in 131 patients using polysomnography to see how sleep disturbances relate to clinical outcomes, particularly focusing on those with acute respiratory failure.
- Findings showed that while deep sleep is maintained in certain cases, REM sleep is often disrupted, and a complete lack of REM sleep correlates with worse clinical outcomes in patients.
Background: Reconnection to the ventilator for 1 h following a successful spontaneous breathing trial (SBT) may reduce reintubation rates compared with direct extubation. However, the physiologic mechanisms leading to this effect are unclear.
Research Question: Does reconnection to the ventilator for 1 h reverse alveolar derecruitment induced by SBT, and is alveolar derecruitment more pronounced with a T-piece than with pressure-support ventilation (PSV)?
Study Design And Methods: This is an ancillary study of a randomized clinical trial comparing SBT performed with a T-piece or with PSV.
Article Synopsis
- * In a study involving 72 extubated patients from an ICU, researchers examined the relationship between sleep continuity measured by EEG and patient-reported sleep quality using the Richards-Campbell sleep questionnaire (RCSQ) and a simpler sleep numeric rating scale (sleep-NRS).
- * Results indicated a significant correlation between sleep continuity and sleep-NRS scores, whereas no correlation was found with RCSQ, suggesting that the numeric rating scale may be a more straightforward tool for assessing sleep quality in ICU patients.
Article Synopsis
- The study investigated the effect of sleep deprivation on respiratory muscle performance in ICU patients with acute hypoxemic respiratory failure, focusing on the relationship between sleep quality and the need for intubation.* -
- A total of 34 subjects were monitored with polysomnography, revealing that while total sleep time was relatively maintained, many experienced inadequate REM sleep, with 38% having none at all.* -
- The results indicated no significant difference in sleep quality between those who required intubation and those who did not, but suggested a potential link between the absence of REM sleep and an increased risk of intubation, warranting further research.*
Objectives: Due to the noisy environment, a very large number of patients admitted to intensive care units (ICUs) suffer from sleep severe disruption. These sleep alterations have been associated with a prolonged need for assisted ventilation or even with death. Sleep scoring in the critically ill is very challenging and requires sleep experts, limiting relevant studies to a few experienced teams.
View Article and Find Full Text PDFBackground: Whereas high-flow nasal cannula (HFNC) oxygen therapy is increasingly used in patients with exacerbation of COPD, the effectiveness of agonist nebulization through HFNC has been poorly assessed. We hypothesized that salbutamol vibrating-mesh nebulization through HFNC improves pulmonary function tests in subjects with COPD.
Methods: We conducted a physiological crossover study including subjects admitted to the ICU for severe exacerbation of COPD.
Background: Sleep had never been assessed immediately after extubation in patients still in the ICU. However, sleep deprivation may alter respiratory function and may promote respiratory failure. We hypothesized that sleep alterations after extubation could be associated with an increased risk of post-extubation respiratory failure and reintubation.
View Article and Find Full Text PDFStudy Objectives: Sleep deprivation alters inspiratory endurance by reducing inspiratory motor output. Vagal tone is involved in exercise endurance. This study aimed to investigate the effect of sleep deprivation on vagal tone adaptation in healthy subjects performing an inspiratory effort.
View Article and Find Full Text PDFSleep deprivation can alter endurance of skeletal muscles, but its impact on respiratory command is unknown. We aimed to assess the effect of sleep deprivation on respiratory motor output and inspiratory endurance. Inspiratory endurance was investigated twice in random order, following a normal sleep night and a sleepless night.
View Article and Find Full Text PDFSleep is markedly altered in intensive care unit (ICU) patients and may alter respiratory performance. Our objective was to assess the impact of sleep alterations on weaning duration.We conducted a prospective physiological study at a French teaching hospital.
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