Publications by authors named "Christophe Kerninon"
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Synopsis of recent research by authors named "Christophe Kerninon"
- Christophe Kerninon’s research primarily focuses on the differentiation and development of oligodendrocyte precursor cells (OPCs) and their roles in myelination and remyelination processes within the central nervous system, particularly in the context of demyelinating diseases like Multiple Sclerosis.
- His findings highlight several molecular pathways, including the roles of transcription factors such as SOX17 and Olig2, and signaling mechanisms involving vitamin D and retinoid X receptors, which collectively influence OPC differentiation and maturation.
- Kerninon’s work also addresses the impact of pathological environments on OPC functionality, revealing that demyelination can revert OPCs to a less mature state, impairing myelin repair, underscoring the need for therapeutic strategies targeting these pathways to enhance remyelination.
