Publications by authors named "Christophe Kamungu Mapendano"
Article Synopsis
- * Data from the Danish Metastatic Melanoma Database (DAMMED) involved 79 treatment-naive patients, showing a complete response rate of 16.5% and an overall response rate of 46.9%.
- * The 6-month progression-free survival rate was 53.5%, and the median overall survival was not reached, indicating that the real-world results align closely with those from previous phase II trials.
Aim: Our goal was to describe a precision medicine program in a regional academic hospital, characterize features of included patients and present early data on clinical impact.
Materials And Methods: We prospectively included 163 eligible patients with late-stage cancer of any diagnosis from June 2020 to May 2022 in the Proseq Cancer trial. Molecular profiling of new or fresh frozen tumor biopsies was done by WES and RNAseq with parallel sequencing of non-tumoral DNA as individual reference.
Genetic alterations identified in adjacent normal appearing tissue in bladder cancer patients are indicative of a field disease. Here we assessed normal urothelium transformation and intra-tumour heterogeneity (ITH) in four patients with bladder cancer. Exome sequencing identified private acquired mutations in a lymph node metastasis and local recurrences.
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