Publications by authors named "Christophe Grenet"
Several studies suggest that exposure to environmental pollutants is partly responsible for testicular pathologies that have considerably increased over the last decades (cryptorchidism, hypospadias, cancer, decrease in the number of ejaculated spermatozoa). However, the cellular and molecular mechanisms involved in this reprotoxicity remain mostly unknown. One of the challenges of the european regulation REACH is to improve the knowledge on the chemical, toxic and ecotoxic properties of substances used in everyday life.
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- Metargidin, a protein involved in angiogenesis, interacts with integrins on endothelial cells, which are crucial for blood vessel formation.
- A recombinant human disintegrin domain (RDD) was produced and shown to inhibit processes like endothelial cell proliferation and migration in vitro, significantly affecting capillary formation.
- In vivo experiments demonstrated that RDD reduced tumor growth and metastasis in mice, indicating its potential as a therapeutic agent in cancer treatment.