Cerebral tissue pO response to treadmill exercise in awake mice.

We exploited two-photon microscopy and Doppler optical coherence tomography to examine the cerebral blood flow and tissue pO response to forced treadmill exercise in awake mice. To our knowledge, this is the first study performing both direct measure of brain tissue pO during acute forced exercise and underlying microvascular response at capillary and non-capillary levels. We observed that cerebral perfusion and oxygenation are enhanced during running at 5 m/min compared to rest.