Publications by authors named "Christophe Claessens"
Background: Central aortic stiffness is established as a reliable measure of cardiovascular disease. While pulse wave velocity (PWV) analysis measures arterial distensibility, risk profile of cardiovascular diseases can be expanded with following pulse wave analysis measurements: central aortic systolic blood pressure (CABPS), central aortic pulse pressure (CAPP), central aortic reflection magnitude (CARM), central aortic augmented pressure (CAAP) and central aortic augmentation index (CAAIx). The aim of this study is to evaluate the clinical usefulness and importance of pulse wave analysis measurements in specific cardiovascular conditions and diseases, both in term of diagnosis and therapeutic monitoring.
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- Advanced therapies like biologics and small molecules have been approved for treating moderate-to-severe ulcerative colitis, but patients with isolated proctitis were often excluded from clinical trials, creating an evidence gap for this specific group.
- In a study of 167 patients with active ulcerative proctitis who had already failed conventional treatments, it was found that 36.3% achieved short-term steroid-free remission, with better outcomes for bionaive patients and those treated with vedolizumab.
- The results support the effectiveness and safety of advanced therapies for ulcerative proctitis, suggesting that future trials should include these patients to better understand treatment options.
Background: Elective switching between anti-tumour necrosis factor (TNF) agents not necessarily dictated by efficacy or tolerability occurs in clinical practice. A study was undertaken to evaluate prospectively the impact of elective switching of patients with Crohn's disease well controlled with intravenous infliximab to subcutaneous adalimumab in a controlled trial.
Methods: An open-label randomised single-centre trial recruited 73 patients with ongoing response to at least 6 months of scheduled maintenance infliximab.
Cardiac rehabilitation improves the subjective condition of the patient; but are there associated structural and functional cardiac adaptations? The study group consisted of 39 patients with an inferior infarction and 21 patients with an anterior infarction, treated by surgical revascularization followed by 4 months of cardiac rehabilitation. Maximal exercise testing and Doppler echocardiography were performed before and after the rehabilitation program. Performance capacity was significantly improved after cardiac rehabilitation, but left ventricular function remained unchanged on Doppler imaging.
View Article and Find Full Text PDFIschaemic colitis is the most frequent form of mesenteric ischaemia and is most frequently the result of a non-occlusive disease process. Elderly patients, especially those with underlying co-morbid conditions are at greatest risk. The symptoms are often non-specific and diagnosis is usually established upon the clinical setting and colonoscopy with biopsy.
View Article and Find Full Text PDFBackground: The purpose of the study was detection of coronary atherosclerosis and identification of persons at risk by means of non-invasive examination of the carotid and peripheral arteries.
Material/methods: Investigation of 366 patients: 229 males and 137 females divided into groups according to age and the severity of the coronary atherosclerotic lesions. Only patients with a coronary stenosis of more than 90%, who needed angioplasty or coronary bypass surgery, were included.