Publications by authors named "Christophe Bonnet"

Leukostasis is a classic and well-known complication of acute leukemia when major hyperleukocytosis is present. It affects some organs, notably the central nervous system. The symptoms of cerebral leukostasis are diverse and vary in intensity.

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The 2-deoxy-2-[F]fluoro-D-glucose positron emission tomography combined with computed tomography (PET/CT) has contributed to outcome improvement of patients with lymphoma. The use of [F]FDG PET/CT for staging and response assessment is successfully applied both in routine clinical practice and in clinical trials. The challenges lie in enhancing the outcomes of lymphoma patients, particularly those with advanced or refractory/relapsed disease, and to minimize the long-term toxicity associated with treatments, including radiation therapy.

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  • * Out of 89 participants, the treatment achieved a complete metabolic response (CMR) in 77.5% of cases after 6 cycles, with a tolerance for side effects, as 88% completed the regimen despite a 20% rate of serious adverse events.
  • * In long-term follow-up (median 42 months), the 4-year progression-free survival rate was 50% and overall survival 69%, with factors like liver involvement and lymphopenia affecting outcomes.
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Patients with relapsed or refractory (R/R) peripheral T-cell lymphomas (PTCL) have a poor prognosis. Bendamustine (B) and brentuximab-vedotin (Bv) have shown interesting results in this setting. However, little information is available about their efficacy in combination.

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  • ALK-negative anaplastic large cell lymphoma (ALCL) has subgroups based on gene rearrangements, specifically DUSP22-R and TP63-R, which show different survival rates, making the impact of DUSP22 results unclear.
  • In a study involving 104 newly diagnosed ALCL patients, 45% showed DUSP22-R, indicating that tumors with this rearrangement had different characteristics, including more CD3 expression and more frequent bone involvement.
  • The 5-year progression-free survival (PFS) was significantly higher in patients with DUSP22-R compared to those without, and while both performance status and DUSP22 status affected PFS, only performance status influenced overall survival (OS); patients receiving brent
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  • Doctors studied a new treatment called BV-AVD for patients with a tough type of cancer called early-stage unfavorable Hodgkin lymphoma.
  • * The study involved 170 patients who either received BV-AVD or a standard treatment called ABVD and checked how many were cancer-free after two rounds of treatment.
  • * The results showed that more patients treated with BV-AVD were cancer-free compared to those who had ABVD.
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  • Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an aggressive, rare form of T-cell lymphoma mainly found in Asia, with a clinical study conducted on 71 European patients showing a median age of 67 years.
  • Most patients had gastrointestinal symptoms requiring emergency surgery, with around 40% diagnosed at stage IV, and tumors were classified into typical and atypical morphologies sharing similar immunophenotypic profiles.
  • The study highlighted significant genetic alterations, including mutations in genes like MYC, STAT5B, and TP53, which are associated with poor survival outcomes and treatment resistance, indicating the high clinical risk of MEITL.
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Sarcoidosis and lymphoma often share common features on F-FDG PET/CT, such as intense hypermetabolic lesions in lymph nodes and multiple organs. We aimed at developing and validating radiomics signatures to differentiate sarcoidosis from Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL). We retrospectively collected 420 patients (169 sarcoidosis, 140 HL, and 111 DLBCL) who underwent pretreatment F-FDG PET/CT at the University Hospital of Liege.

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In the post-rituximab era, patients with relapsed/refractory non-Hodgkin B-cell lymphoma (R/R B-NHL) responding to a platinum salt-based salvage regimen can potentially be cured after intensification followed by autologous stem cell transplantation, with the quality of the response to salvage predicting survival. The Bruton tyrosine kinase inhibitor ibrutinib, given as monotherapy or combined with other molecules, has proven effective in numerous B-cell lymphomas. To evaluate the safety of the combination of ibrutinib, rituximab, dexamethasone, and cytarabine with either cisplatin (R-DHAP) or oxaliplatin (R-DHAOx), we conducted a multicenter Phase 1b-II study in transplant-eligible R/R B-NHL patients, with ibrutinib given using a 3-by-3 dose-escalation design.

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Nodal peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) with cytotoxic phenotype is overall rare, with most reports coming from Asia. Given its elusive pathobiology, we undertook a clinicopathological and molecular study of 54 Western patients diagnosed with PTCL, NOS expressing cytotoxic molecules, within a lymph node. More commonly males (M/F-2,6/1) with median age of 60 years were affected.

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Purpose: The AHL2011 study (ClinicalTrials.gov identifier: NCT01358747) demonstrated that a positron emission tomography (PET)-driven de-escalation strategy after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) provides similar progression-free survival (PFS) and overall survival (OS) and reduces early toxicity compared with a nonmonitored standard treatment. Here, we report, with a prolonged follow-up, the final study results.

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Background: Muscle depletion (MD) assessed by computed tomography (CT) has been shown to be a predictive marker in solid tumors, but has not been assessed in non-Hodgkin's lymphomas. Despite software improvements, MD measurement remains highly time-consuming and cannot be used in clinical practice.

Methods: This study reports the development of a Deep-Learning automatic segmentation algorithm (DLASA) to measure MD, and investigate its predictive value in a cohort of 656 diffuse large B cell lymphoma (DLBCL) patients included in the GAINED phase III prospective trial (NCT01659099).

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  • Primary mediastinal B-cell lymphoma (PMBL) predominantly affects young females and has an unclear first-line treatment standard, prompting a large study across 25 centers in France and Belgium to assess patient outcomes.
  • The study included 313 patients treated with different regimens (R-ACVBP and R-CHOP) and found comparable end-of-treatment metabolic response rates, although R-ACVBP showed higher toxicity like febrile neutropenia and mucositis.
  • Results indicated three-year progression-free survival rates of 89.4% for both R-ACVBP and R-CHOP14, while R-CHOP21 was lower at 74.7%; a higher baseline tumor volume was linked
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The low abundance of Hodgkin/Reed-Sternberg (HRS) cells in lymph node biopsies in classical Hodgkin lymphoma (cHL) complicates the analysis of somatic genetic alterations in HRS cells. As circulating cell-free DNA (cfDNA) contains circulating tumor DNA (ctDNA) from HRS cells, we prospectively collected cfDNA from 177 patients with newly diagnosed, mostly early-stage cHL in a monocentric study at Leuven, Belgium (n = 59) and the multicentric BREACH study by Lymphoma Study Association (n = 118). To catalog the patterns and frequencies of genomic copy number aberrations (CNAs), cfDNA was sequenced at low coverage (0.

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Purpose: The prognosis of elderly patients with diffuse large B-cell lymphoma (DLBCL) is worse than that of young patients. An attenuated dose of chemotherapy-cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab (R-miniCHOP)-is a good compromise between efficacy and safety in very elderly patients. In combination with R-CHOP (R2-CHOP), lenalidomide has an acceptable level of toxicity and may mitigate the negative prognosis of the non-germinal center B-cell-like phenotype.

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  • Rituximab combined with polychemotherapy is the standard treatment for diffuse large B-cell lymphoma (DLBCL), and the GAINED trial compared its effectiveness against obinutuzumab in transplant-eligible patients aged 18-60 with untreated DLBCL.
  • The trial enrolled 670 patients, with a primary goal of achieving a significant 8% improvement in 2-year event-free survival (EFS) in the obinutuzumab group, but the results showed similar EFS rates for both treatments (59.8% for obinutuzumab vs 56.6% for rituximab).
  • Additionally, while there was no superiority of obinutuzumab over rituximab, patients
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The French society of clinical biology "Biochemical markers of COVID-19" has set up a working group with the primary aim of reviewing, analyzing and monitoring the evolution of biological prescriptions according to the patient's care path and to look for markers of progression and severity of the disease. This study covers all public and private sectors of medical biology located in metropolitan and overseas France and also extends to the French-speaking world. This article presents the testimonies and data obtained for the "Overseas and French-speaking countries" sub-working group made up of 45 volunteer correspondents, located in 20 regions of the world.

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Four hybrid double-chain surfactants with a maltose polar head were synthesized. The apolar domain consists of a hydrogenated chain, and a partially fluorinated chain made of a propyl hydrogenated spacer terminated by a perfluorinated core of various lengths. Their water solubility was found to be lower than 1 g/L irrespective of the length of both chains.

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Background: Lenalidomide plus rituximab is approved to treat patients with relapsed or refractory follicular lymphoma. Obinutuzumab has been shown to enhance antibody-dependent cellular cytotoxicity, phagocytosis, and direct B-cell killing better than rituximab. Our aim was to determine the activity and safety of lenalidomide plus obinutuzumab in previously treated patients with relapsed or refractory follicular lymphoma.

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The detection rates of whole-body combined [ F]NaF/[ F]FDG positron emission tomography combined with computed tomography (PET/CT), CT alone, whole-body magnetic resonance imaging (WB-MRI), and X-ray were prospectively studied in patients with treatment-requiring plasma cell disorders The detection rates of imaging techniques were compared, and focal lesions were classified according to their anatomic location. Twenty-six out of 30 initially included patients were assessable. The number of focal lesions detected in newly diagnosed patients (n = 13) and in relapsed patients (n = 13) were 296 and 234, respectively.

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Sensitive, robust and stable sensors are required to bring biosensing techniques from the forefront of research to clinical and commercial settings. To this end, we report on the development of new robust plasmonic sensors consisting of gold nano-bipyramids (BPs) grafted to a glass substrate via silanization, associated with a novel setup based on Spatial Modulation Spectroscopy allowing the measurement of the optical response of individual nano-objects in a liquid environment. We thereby show that changes in the refractive index of the medium around individual silanized BPs can be detected by measuring their plasmonic shift with sensitivities comparable to values reported elsewhere and in good agreement with theoretical calculations.

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The acoustic vibrations of single monomers and dimers of gold nanoparticles were investigated by measuring for the first time their ultralow-frequency micro-Raman scattering. This experiment provides access not only to the frequency of the detected vibrational modes but also to their damping rate, which is obscured by inhomogeneous effects in measurements on ensembles of nano-objects. This allows a detailed analysis of the mechanical coupling occurring between two close nanoparticles (mediated by the polymer surrounding them) in the dimer case.

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An observational study was set up to assess the feasibility of [F]FPRGD PET/CT for imaging patients with multiple myeloma (MM) and to compare its detection rate with low dose CT alone and combined [F]NaF/[F]FDG PET/CT images. Four patients (2 newly diagnosed patients and 2 with relapsed MM) were included and underwent whole-body PET/CT after injection of [F]FPRGD. The obtained images were compared with results of low dose CT and already available results of a combined [F]NaF/[F]FDG PET/CT.

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Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive non-Hodgkin lymphomas with poor outcomes on current therapy. We investigated whether response assessed with PET/CT combined with baseline total metabolic tumor volume (TMTV) could detect early relapse or refractory disease. From 7 European centers, 140 patients with nodal PTCL who underwent baseline PET/CT were selected.

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