Publications by authors named "Christophe Barisien"
Chimeric Antigen Receptor (CAR) therapy has led to great successes in patients with leukemia and lymphoma. Umbilical Cord Blood (UCB), stored in UCB banks, is an attractive source of T cells for CAR-T production. We used a third generation CD123 CAR-T (CD28/4-1BB), which was previously developed using an adult's Peripheral Blood (PB), to test the ability of obtaining CD123 CAR-T from fresh or cryopreserved UCB.
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- Convalescent plasma therapy is being explored as a treatment for critically ill COVID-19 patients, focusing on selecting donors based on their neutralizing antibody levels.
- A study analyzed T cell responses and humoral responses in 115 donors, discovering high reactivity against key SARS-CoV-2 proteins and a majority showing poly-specific T cell responses.
- The research concluded that the strength and diversity of T cell responses in donors correlate strongly with their antibody levels, suggesting that combining T cell assessments with antibody measurements could improve donor selection and evaluation of vaccine efficacy.
The management of hyperleukocytosis or thrombocytosis by therapeutic cytapheresis in the early 21 st century is far from codified (universal). Therapeutic cytapheresis have been proposed to achieve more rapid cytoreduction in peripheral blood than old universal support in order to quickly prevent potential complications. But, there are no randomized studies demonstrating the superiority of cytapheresis over other treatments alone.
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