The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene as a protective factor in corona virus disease 2019 (COVID-19).

Background And Aims: Several factors, such as hypertension and diabetes mellitus, are known to influence the course of coronavirus disease 2019 (COVID-19). However, there is currently little information on genetic markers that influence the severity of COVID-19. In this study, we specifically investigated the single nucleotide polymorphism (SNP) rs4986790 in the gene to identify a universal marker for preclinical prediction of COVID-19 disease progression.

The c.825CT (rs5443) polymorphism and protection against fatal outcome of corona virus disease 2019 (COVID-19).

Albeit several factors which influence the outcome of corona virus disease (COVID-19) are already known, genetic markers which may predict the outcome of the disease in hospitalized patients are still very sparse. Thus, in this study, we aimed to analyze whether the single-nucleotide polymorphism (SNP) rs5443 in the gene , which was associated with higher T cell responses in previous studies, might be a suitable biomarker to predict T cell responses and the outcome of COVID-19 in a comprehensive German cohort. We analyzed the influence of demographics, pre-existing disorders, laboratory parameters at the time of hospitalization, and rs5443 genotype in a comprehensive cohort (N = 1570) on the outcome of COVID-19.