Publications by authors named "Christoph Radosa"

Interventional oncology (IO) employs various techniques to enable minimally invasive, image-guided treatment of tumor diseases with both curative and palliative goals. Additionally, it significantly contributes to managing tumor-related and perioperative complications, offering diverse supportive procedures for patients at all stages of their diseases. The execution of IO procedures places unique demands on the equipment, personnel, and structural organization of radiological clinics, necessitating specific expertise from interventional radiologists.

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Purpose: To assess the accuracy of preoperative sonographic staging in patients with primary invasive breast cancer.

Methods: We retrospectively analyzed a prospectively kept service database of patients with newly diagnosed, unifocal, cT1-3, invasive breast cancer. All patients were diagnosed at a single center institution between January 2013 and December 2021.

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The demand for fertility-sparing surgery (FSS) has increased in the last decade due to increased maternal age, increased incidence of ovarian malignancies in younger patients, and technical advances in surgery. Data on oncological safety and fertility outcomes of patients with ovarian cancer after laparoscopic FSS are sparse, but some retrospective studies have shown that open FSS may be offered to selected patients. We assessed the role of minimally invasive FSS in comparison with radical surgery (RS) in terms of oncological safety and reproductive outcomes after FSS in this multicenter study.

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Purpose: The COVID-19 pandemic led to the implementation of severe restrictions on public life in Germany and a reduction in the number of non-COVID patients presenting for care. The aim of this study was to measure the impact on the number of therapeutic interventional oncology procedures in relation to diagnostic imaging studies at a high-volume radiology department.

Materials And Methods: The numbers of therapeutic interventional oncology procedures and diagnostic CT/MRI examinations for the years 2010 to 2021 were extracted using the hospital information system.

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Article Synopsis
  • The study looked at whether doing a second scan of the chest (thoracic CT) helps ICU patients with infections after surgery on the tummy area (abdominopelvic surgery).
  • They checked 143 chest and tummy scans and found that the chest scan showed 297 problems, but only 26 could only be seen on the chest scan.
  • Using the chest scan didn’t really change much in how patients were treated, helping only a tiny bit (3.5% for infections and 0.7% for overall management).
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Objective: To evaluate how hysterectomy performed for benign gynecologic pathologies affects the quality of life and sexual function of patients aged 35 years or younger, and if outcomes differ according to the surgical technique.

Methods: Seventy-three patients who underwent total laparoscopic hysterectomy (TLH), supracervical laparoscopic hysterectomy (SLH), or vaginal hysterectomy (VH) for benign uterine disorders between April 2014 and June 2020 at the Department of Gynecology and Obstetrics, Saarland University Hospital, Homburg, Germany, were enrolled in this prospective observational cohort study. Quality of life and sexual function were assessed preoperatively and 6 months postoperatively using standardized validated questionnaires: the European Quality of Life Five-Dimension Scale (EQ-5D) and the Female Sexual Function Index (FSFI).

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Radiological reporting errors have a direct negative impact on patient treatment. The purpose of this study was to investigate the contribution of clinical information (CI) in radiological reporting of oncological imaging and the dependence on the radiologists’ experience level (EL). Sixty-four patients with several types of carcinomas and twenty patients without tumors were enrolled.

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  • The study assessed the accuracy of preoperative ultrasound in predicting limited axillary disease (LAD) in early-stage breast cancer patients.
  • It included a retrospective analysis of data from over 2000 patients treated between 2015 and 2020, evaluating outcomes for one and two suspicious lymph nodes.
  • Results indicated high sensitivity and negative predictive value for LAD prediction, particularly in patients with one suspicious lymph node, while highlighting the inverse relationship between the number of suspicious lymph nodes and prediction accuracy.
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Background: Aortoiliac stenosis is common cause of peripheral arterial disease (PAD), which is particularly prevalent in older age (> 60 years) with a prevalence of 20%. In early stages (TASC [Trans-Atlantic Inter-Society Consensus] II A/B), these stenoses can be successfully treated by endovascular procedures. For more complex aortoiliac stenoses (TASC II C/D), open surgical treatment was the primary treatment in the past.

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  • Interventional oncology has emerged as a significant treatment option alongside traditional therapies for tumors, showing growing efficiency and adoption in clinical practice.
  • A comprehensive analysis of the DeGIR registry data from 2018 to 2019 highlighted an increase in both participating clinics and the number of oncological interventions, indicating a positive trend in nationwide care.
  • Despite the rise in total interventions, the average number per clinic slightly decreased, suggesting a broader distribution of services across more facilities while still meeting certification standards for training centers.
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Purpose: Chronic mesenteric ischemia (CMI) is a rare but life-threatening disease. This study reviewed outcomes in patients treated surgically for CMI by open treatment (OT) and endovascular treatment (ET), analyzing risk factors for endovascular failure.

Methods: Clinical data for 36 patients treated for CMI from 2007 to 2017 were retrospectively analyzed.

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  • The study looked at how well two types of scans (F-fluorodeoxyglucose-PET/MRI and MRI) can detect if rectal cancer has come back in patients.
  • Four groups of medical experts reviewed the scans and scored how likely it was that the cancer had returned.
  • Both scans worked well, but the PET/MRI helped doctors feel more sure about their findings and showed fewer unclear cases compared to MRI.
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Purpose: Vaginal cuff dehiscence (VCD) is one of the major surgical complications following hysterectomy with data on incidence rates varying largely and studies assessing risk factors being sparse with contradictive results. The aim of this study was to assess the incidence rate of and risk factors for VCD in a homogenous cohort of women treated for benign uterine pathologies via total laparoscopic hysterectomy (TLH) with standardized follow-up.

Methods: All patients undergoing TLH at the Department of Gynecology and Obstetrics, Saarland University Hospital between November 2010 and February 2019 were retrospectively identified from a prospectively maintained service database.

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Purpose: Preoperative hypertrophy induction of future liver remnant (FLR) reduces the risk of postoperative liver insufficiency after partial hepatectomy. One of the most commonly used methods to induce hypertrophy of FLR is portal vein embolization (PVE). Recent studies have shown that transarterial radioembolization (TARE) also induces hypertrophy of the contralateral liver lobe.

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Purpose: Visceral and renal artery aneurysms (VAA, RAA) are very rare pathologies. Both surgical and endovascular therapies are discussed as therapeutic options for ruptured and non-ruptured aneurysm repair; we describe our experience in the open and endovascular management of these entities.

Methods: Retrospective database analysis of 60 treated VAA and RAA in 59 patients between 1994 and 2020.

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Purpose: Postoperative pulmonary embolism (PE) after pancreatic surgery is a potentially life-threatening complication. However, the magnitude of morbidity and mortality of PE is still uncertain. The present study aims to assess the incidence of PE after pancreatic surgery and analyze its impact on the outcome.

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Purpose: Characterization of intraabdominal fluid collections as postoperative complication is a challenging task. The aim was to develop and validate a new score to differentiate infected from sterile postoperative abdominal fluid collections and to compare it with a published score.

Materials And Methods: From May to November 2015, all patients with postoperative CT and C-reactive protein (CRP) 24 hours before CT-guided drainage were retrospectively included (Group A).

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Background: Evidence from multiple studies have shown the potential of thermal ablative therapies to induce regression of metastases and tumors which are distant from the treated metastases-within the same organ or even in other organs-the so-called abscopal effect. Unfortunately, this effect is most often weak and not always reproducible. Recent developments in systemic therapies showed that immunomodulating drugs are of major interest in patient-tailored tumor therapy due to the fact that they are able to enhance the treatment effect of conventional chemotherapy.

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Purpose: To assess whether the application of a preparatory micro-enema reduces gas-induced susceptibility artefacts on diffusion-weighted MRI of the prostate.

Methods: 114 consecutive patients who received multiparametric 3 T MRI of the prostate at our institution were retrospectively enrolled. 63 patients self-administered a preparatory micro-enema prior to imaging, and 51 patients underwent MRI without bowel preparation.

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Purpose: Postpancreatectomy hemorrhage (PPH) is one of the leading causes of mortality after pancreatic resection. Late onset PPH is most often treated using a transarterial approach. The aim of this study was to analyze risk factors for in-hospital mortality after endovascular treatment.

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Article Synopsis
  • Laparoscopy has become a common procedure in gynecological surgery, but validated quality indicators for assessing complications and patient satisfaction are not regularly used.
  • This study reviewed the Clavien-Dindo classification for postoperative complications and the Picker Patient Experience Questionnaire (PPE-15) for patient satisfaction among 212 patients at a gynecologic endoscopic referral center.
  • The findings revealed a complication rate of 13.21%, with a significant number of patients reporting issues during their treatment, highlighting the potential effectiveness of these tools for improving care quality in gynecology.
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Purpose: To investigate clinical feasibility, technical success and toxicity of Ho-radioembolization (Ho-RE) as new approach for treatment of hepatocellular carcinomas (HCC) and to assess postinterventional calculation of exact dosimetry through quantitative analysis of MR images.

Materials And Methods: From March 2017 to April 2018, nine patients suffering from HCC were treated with Ho-RE. To calculate mean doses on healthy liver/tumor tissue, MR was performed within the first day after treatment.

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