Laser-induced fluorescence spectroscopy of 14N18O and its application to breath analysis.

Laser-induced fluorescence (LIF) spectroscopy is an efficient tool for the detection of low nitric oxide (NO) concentrations down to the parts per trillion (ppt) range. The isotopic selectivity of this method provides a broad potential of applications. Whereas (14)N(16)O and (15)N(16)O have been described extensively this is not the case for the (14)N(18)O isotopologue.

Non-invasive and isotope-selective laser-induced fluorescence spectroscopy of nitric oxide in exhaled air.

The detection of nitric oxide (NO) is of considerable medical interest. NO is involved in a multitude of mammal physiological processes, and various non-invasive concentration determination methods for NO have been developed during the last few years. Regarding time resolved metabolism behavior the quantitative determination of the (15)N(16)O-isotopologue in combination with (15)N-labeled drugs and amino acids is a central interest of current medical research.