Publications by authors named "Christoph Leibl"
Introduction: Photodynamic inactivation of bacteria (PIB) may be a supportive antimicrobial approach for use in endodontics, but sufficient activation of photosensitizers (PS) in root canals is a critical point. Therefore, aim of this study was to evaluate the ability of PS absorbing blue (TMPyP) or red light (Methylene Blue; MB) for light activation through human dental hard and simulated surrounding tissue to inactivate root canal bacteria.
Methods: A tooth model was fabricated with a human premolar and two molars in an acrylic resin bloc simulating the optical properties of a porcine jaw.
Increasing antibiotic resistances in microorganisms create serious problems in public health. This demands alternative approaches for killing pathogens to supplement standard treatment methods. Photodynamic inactivation of bacteria (PIB) uses light activated photosensitizers (PS) to generate reactive oxygen species immediately upon illumination, inducing lethal phototoxicity.
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- The study aimed to show that blue light from a LED light-curing unit can kill the periodontal pathogen Aggregatibacter actinomycetemcomitans (AA) using its own photosensitizers.
- Planktonic cultures of AA and Escherichia coli were treated with blue light, revealing that a specific light dose significantly reduced viable AA bacteria but had no effect on E. coli.
- Spectroscopic analysis confirmed that the lysed AA produced singlet oxygen when exposed to blue light, suggesting the potential for using this method in treating periodontitis by inactivating AA.