Publications by authors named "Christoph Hoppe"
Article Synopsis
- Thyroid hormones and their receptors play a significant role in reducing liver triglycerides, suggesting that thyroid hormone analogs may help treat liver fat accumulation.
- MGL-3196, a new thyroid hormone analog, shows promise for targeting the liver without negative side effects associated with other receptor types, specifically TRα.
- The study found that MGL-3196 is effectively taken up by liver cells through the transporter OATP1B1 and selectively activates the TRβ receptor more than TRα, making it a strong candidate for therapeutic applications in liver conditions.
Context: 3,5,3'-L-triiodothyronine (T3) is a potent inducer of hepatocyte proliferation via the Wnt/β-catenin signaling pathway. Previous studies suggested the involvement of rapid noncanonical thyroid hormone receptor (TR) β signaling, directly activating hepatic Wnt/β-catenin signaling independent from TRβ DNA binding. However, the mechanism by which T3 increases Wnt/β-catenin signaling in hepatocytes has not yet been determined.
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