Selective laser sintering (SLS) is an established method to produce dimensionally accurate scaffolds for tissue engineering (TE) applications, especially in bone. In this context, the FDA-approved, biodegradable polymer poly(ε-caprolactone) (PCL) has been suggested as a suitable scaffold material. However, PCL scaffold mechanical stability - an attribute of particular importance in the field of bone TE - was not considered as a primary target for SLS process parameters optimization so far.
View Article and Find Full Text PDFSince large bone defects cannot be healed by the body itself, continuous effort is put into the development of 3D scaffolds for bone tissue engineering. One method to fabricate such scaffolds is selective laser sintering (SLS). However, there is a lack of solvent-free prepared microparticles suitable for SLS.
View Article and Find Full Text PDFComplex 3D scaffolds with interconnected pores are a promising tool for bone regeneration. Such 3D scaffolds can be manufactured by selective laser sintering (SLS) from biodegradable composite powders. However, the mechanical strength of these scaffolds is often too low for medical application.
View Article and Find Full Text PDFAgricultural intensification drives biodiversity loss and shapes farmers' profit, but the role of legacy effects and detailed quantification of ecological-economic trade-offs are largely unknown. In Europe during the 1950s, the Eastern communist bloc switched to large-scale farming by forced collectivization of small farms, while the West kept small-scale private farming. Here we show that large-scale agriculture in East Germany reduced biodiversity, which has been maintained in West Germany due to >70% longer field edges than those in the East.
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