Publications by authors named "Christoph F Kollmann"
Article Synopsis
- Researchers discovered that 4-octyl itaconate (4-OI) can enhance the effects of an oncolytic virus, VSVΔ51, in resistant cancer cells and models, leading to better treatment outcomes.
- The mechanism involves 4-OI suppressing antiviral immunity in cancer cells by modifying specific proteins, which suggests that combining metabolite-derived drugs with oncolytic viruses could significantly improve cancer treatment.
DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING also activates other pathways, including apoptosis. Here, we report that STING-dependent induction of apoptosis in macrophages occurs through the intrinsic mitochondrial pathway and is mediated via IRF3 but acts independently of gene transcription.
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