Cognitive DDx Assistant in Rare Diseases.

There are between 6,000 - 7,000 known rare diseases today. Identifying and diagnosing a patient with rare disease is time consuming, cumbersome, cost intensive and requires resources generally available only at large hospital centers. Furthermore, most medical doctors, especially general practitioners, will likely only see one patient with a rare disease if at all.

Electromagnetic tracking for femoral derotation osteotomy-an in vivo study.

Femoral derotation osteotomy delivers good to excellent results in the treatment of rotational gait abnormalities and especially in internal rotation gait. The outcome of the procedure has been evaluated in numerous short- and long-term studies. Although reasons for recurrence and over-/under-correction have been unveiled in earlier studies the mechanisms are still not fully understood.

Electromagnetic bone segment tracking to control femoral derotation osteotomy-A saw bone study.

Correction of rotational gait abnormalities is common practice in pediatric orthopaedics such as in children with cerebral palsy. Femoral derotation osteotomy is established as a standard treatment, however, different authors reported substantial variability in outcomes following surgery with patients showing over- or under-correction. Only 60% of the applied correction is observed postoperatively, which strongly suggests intraoperative measurement error or loss of correction during surgery.

Serum levels of the Th1 chemoattractant interferon-gamma-inducible protein (IP) 10 are elevated in patients with essential hypertension.

Growing evidence shows that inflammation has a pivotal role in the pathophysiology of essential hypertension (EH). Although it has been acknowledged that target organ damage involves an inflammatory response, most work has focused on the role of macrophages, but T lymphocytes have recently become the center of interest. The goal of our study was to evaluate the role of T-cell-specific cytokines in the pathogenesis of EH.