Publications by authors named "Christoph Aszyk"
In chronic lymphocytic leukemia (CLL), epigenetic alterations are considered to centrally shape the transcriptional signatures that drive disease evolution and underlie its biological and clinical subsets. Characterizations of epigenetic regulators, particularly histone-modifying enzymes, are very rudimentary in CLL. In efforts to establish effectors of the CLL-associated oncogene T-cell leukemia 1A (TCL1A), we identified here the lysine-specific histone demethylase KDM1A to interact with the TCL1A protein in B cells in conjunction with an increased catalytic activity of KDM1A.
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- Upregulation of the TCL1A proto-oncogene is linked to various aggressive B-cell and T-cell cancers, but its mechanisms, especially in the nucleus, are not fully understood.
- Research showed that TCL1A influences lymphomagenesis in mouse models by altering nuclear organization and interacts with proteins that regulate the cell cycle and DNA repair, notably CDC20.
- High levels of TCL1A correlate with faster cell cycle transitions, increased chromosome missegregation, and aneuploidy, suggesting TCL1A disrupts normal cell cycle control, potentially leading to more aggressive forms of cancer.
Pulmonary malignancies with neuroendocrine differentiation represent a rare subclass of lung carcinomas, which vary in the extent of differentiation and grade of biological aggressiveness. In particular, neuroendocrine tumors are classified into well differentiated typical and atypical carcinoids as well as poorly differentiated large cell neuroendocrine and small cell lung carcinomas. Tiny MicroRNAs have been identified as reliable classifiers in distinct cancer types and seem to play important roles in cellular processes like regulation of cell growth, differentiation and apoptosis.
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