Publications by authors named "Christoffer Fyllgraf Christensen"
Background: Genetic variants in titin (TTN) are associated with dilated cardiomyopathy (DCM) and skeletal myopathy. However, the skeletal muscle phenotype in individuals carrying heterozygous truncating TTN variants (TTNtv), the leading cause of DCM, is understudied.
Objectives: This study aimed to assess the skeletal muscle phenotype associated with TTNtv.
Here, we present a protocol for a randomized, double-blind, placebo-controlled, crossover trial to evaluate the effects of a continuous intravenous infusion of a native liver-derived hormone, liver-expressed antimicrobial peptide 2 (LEAP2), on postprandial glucose metabolism, appetite and satiety sensations, and ad libitum food intake in humans. We describe the preparation of the exogenous hormone administration and participants. We then detail the liquid mixed meal, ad libitum meal test, and blood sampling procedures for assessing postprandial glucose metabolism and food intake.
View Article and Find Full Text PDFBackground: According to patterns of inheritance and incomplete penetrance, fewer than half of relatives to dilated cardiomyopathy probands will develop disease.
Objectives: The purpose of this study was to investigate the prevalence and incidence, and to identify predictors of developing familial dilated cardiomyopathy (FDC) in relatives participating in family screening.
Methods: The study was a retrospective, longitudinal cohort study of families screened and followed from 2006 to 2020 at a regional assembly of clinics for inherited cardiomyopathies.
Article Synopsis
- The study examined complications within 30 days of first-time catheter ablation for atrial fibrillation (AF) in patients aged ≥ 75 years compared to those aged 65-74 years.
- No significant difference in the rate of complications, including cardiac issues and death, was found between the two age groups, indicating similar safety profiles.
- Additionally, there was no notable difference in one-year AF relapse rates, suggesting that older patients do not face higher risks or reduced effectiveness from the procedure compared to younger patients.
Background: Physical activity has been shown to mitigate the unwanted psychological and physiological side effects of prostate cancer treatments, but sustainable exercise possibilities are limited.
Objective: Our objective was to examine whether football in a real-world setting (i.e.
Purpose: To investigate the risk for first depression, assessed as incident hospital contacts for depression and incident use of antidepressants, among women with breast cancer.
Patients And Methods: Danish national registries were used to identify 1,997,669 women with no diagnosis of cancer or a major psychiatric disorder. This cohort was followed from 1998 to 2011 for a diagnosis of breast cancer and for the two outcomes, hospital contact for depression and redeemed prescriptions for antidepressants.