Publications by authors named "Christoffer F Nielsen"
Article Synopsis
- * The study measured uPARAP levels in various MM sample types and found higher expression in certain MM subtypes, which was not influenced by asbestos exposure or chemotherapy status.
- * Researchers demonstrated that MM cell lines specifically take up an anti-uPARAP antibody and are sensitive to a therapeutic conjugate of this antibody with a cytotoxin, indicating potential for uPARAP in diagnosing and treating MM.
A key task in developing the field of personalized cancer therapy is the identification of novel molecular targets that enable treatment of cancers not susceptible to other means of specific therapy. The collagen receptor uPARAP/Endo180 is overexpressed by malignant cells in several non-epithelial cancers, notably including sarcomas, glioblastomas and subsets of acute myeloid leukemia. In contrast, in healthy adult individuals, expression is restricted to minor subsets of mesenchymal cells.
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