Publications by authors named "Christine Vourlakou"
The role of kidney biopsy in deciphering diabetic versus non-diabetic origin of kidney disease among patients with type 2 diabetes mellitus and nephrotic range proteinuria: A retrospective study.
Metabol Open
September 2024
Background: Diabetes mellitus (DM) is tightly associated with the increased prevalence of diabetic kidney disease (DKD). Nonetheless, severe renal function impairment and/or nephrotic range-proteinuria could also result from non-diabetic renal disease (non-DRD) among patients with DM. The 'Gold standard' for the differential diagnosis between DKD and non-DRD is kidney biopsy, although no real consensus exists.
View Article and Find Full Text PDFArticle Synopsis
- - Granular cell tumor is a rare soft tissue neoplasm that can be classified as benign, atypical, or malignant, usually showing slow growth, though the biology and treatment options for these tumors remain unclear due to their rarity.
- - The article discusses an atypical granular cell tumor in a patient who experienced a long period of indolence followed by recurrence after surgical removal, resulting in aggressive progression including metastatic disease.
- - The need for further investigation into treatment options, including chemotherapy and radiation, is highlighted, as current management strategies are largely based on scarce case reports, and outcomes for recurrent or metastatic cases can be severe.
Rapid and reliable testing for clinically actionable EGFR mutations in non-small cell lung cancer using the Idylla platform: a real-world two-center experience in Greece.
Expert Rev Mol Diagn
February 2024
Background: Limited information exists on epidermal growth factor receptor molecular epidemiology in Greece. Next-generation sequencing (NGS) is the recommended method for genotyping in NSCLC. The Idylla Biocartis platform is a fully automated system for actionable mutation detection.
View Article and Find Full Text PDFIntroduction: New Immuno- Checkpoint inhibitors (ICIs) functioning as PD-1- PDL-1 blockers are nowadays used in a majority of anticancer treatments. Many immune- related Adverse Events (irAEs) are published daily; severe skin toxicities, Stevens Johnson/ Toxic Epidermal Necrolysis (SJS/TEN) are seldom reported.
Case Report: Herein, we present two interesting skin sever toxicity cases of lung cancer patients, undergoing PD-1- PDL-1 Immunotherapy.
We describe a critically ill, SARS-CoV-2 positive patient with respiratory failure and thrombotic/livedoid skin lesions, appearing during the course of the disease. The biopsy of the lesions revealed an occlusive, pauci-inflammatory vasculopathy of the cutaneous small vessels characterized by complement and fibrinogen deposition on vascular walls, pointing to a thrombotic vasculopathy. Transmission electron microscopy of the affected skin failed to reveal any viral inclusions.
View Article and Find Full Text PDFPrimary lymphomas of the colon account for 0.5% of all primary colon malignancies. Burkitt´s lymphoma is a B-cell lymphoma with aggressive clinical behavior.
View Article and Find Full Text PDFIntroduction: Sublingual salivary gland neoplasms are extremely rare, accounting for only 0.3-1% of all epithelial salivary gland tumors. Most of the sublingual tumors are malignant, adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) being the most common histological types.
View Article and Find Full Text PDFIntroduction: Dermoid cysts of the floor of the mouth and submandibular space represent an unusual clinical entity.
Case Report: A case of an enlarged median dermoid cyst in a young female adult causing obstruction of the airway is reported.
Discussion: The need of an extraoral and intraoral incision for the removal of the cyst is discussed, along with a review of the literature.