Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study.

Context: Reducing aspiration of gastric contents by placing mechanically ventilated patients in a semirecumbent position has been associated with lower incidences of ventilator-associated pneumonia (VAP). The feasibility and efficacy of this intervention in a larger patient population, however, are unknown.

Objective: Assessment of the feasibility of the semirecumbent position for intensive care unit patients and its influence on development of VAP.

Mycobacteria target DC-SIGN to suppress dendritic cell function.

Mycobacterium tuberculosis represents a world-wide health risk and immunosuppression is a particular problem in M. tuberculosis infections. Although macrophages are primarily infected, dendritic cells (DCs) are important in inducing cellular immune responses against M.