Publications by authors named "Christine Son"
Background: Large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of prostate cancer. The pathogenesis, clinical manifestation, treatment options, and prognosis are uncertain and underreported.
Materials And Methods: A systematic search was conducted in April 2022 through PubMed, Embase, and Cochrane.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) can treat advanced lung cancer but may cause serious heart-related side effects, prompting a study on their cardiotoxicity in patients with or without prior chest radiation.
- The research analyzed data from 194 lung cancer patients treated with ICIs from 2015 to 2018, focusing on the relationship between thoracic radiotherapy timing, heart radiation dose, and the occurrence of cardiotoxic events.
- Findings showed no significant increase in cardiotoxicities among patients receiving concurrent radiation therapy with ICIs, but further prospective studies are needed for confirmation.
Objective: We evaluated the safety of baricitinib 4 mg at 24 weeks for the treatment of moderate to severe rheumatoid arthritis (RA).
Methods: Multiple databases were searched from inception up to November 26, 2019 for randomized controlled trials comparing baricitinib 4 mg with placebo for the treatment of moderate to severe RA. The safety outcomes of interest were the incidence of serious adverse events, adverse events leading to study discontinuation, all infections, and serious infections.