The study assessed how well the Schnider pharmacokinetic model predicts plasma propofol levels in patients with reduced heart function receiving deep sedation.
It involved 34 patients undergoing a procedure, where the model significantly underestimated the actual propofol concentrations, with a mean prediction error of 37%.
BIS values varied greatly among individuals during sedation, indicating that BIS monitoring is not reliable for determining deep sedation levels in this particular patient group.