Time spent in vigorous physical activity is associated with increased exhaled nitric oxide in non-asthmatic adolescents.

Introduction: Physical activity (PA) is important in preventing disease, but endurance elite athletes have increased prevalence of asthma and airway inflammation.

Objectives: We aimed to determine if PA was associated with increased fractional exhaled nitric oxide (FENO ) in asthmatic and non-asthmatic adolescents.

Methods: FENO was recorded (Niox Mino®, Aerocrine AB, Stockholm, Sweden) in 169 adolescents (13-14 years) in a nested case-control analysis from the Environment and Childhood Asthma study, Oslo, 92 adolescents with and 77 without asthma.

Eoxins: a new inflammatory pathway in childhood asthma.

Background: Increased levels of leukotrienes (LTs) in exhaled breath condensate (EBC) are associated with asthma and bronchial hyperresponsiveness (BHR), whereas eicosanoids generated through the 15-lipoxygenase (LO) pathway (15-hydroxyeicosatetraenoic acid [HETE] and eoxins) have been less studied.

Objective: We investigated whether metabolites of the 5- and 15-LO pathways in EBC are associated with childhood asthma, asthma severity, and clinical parameters.

Methods: The present study included 131 school-aged children (27 children with problematic severe asthma, 80 children with mild-to-moderate asthma, and 24 healthy children) from the Severe Asthma Recognized in Childhood study and 19 children with other nonasthmatic chronic lung diseases.

Asthma severity in childhood, untangling clinical phenotypes.

Assessment of childhood asthma severity and asthma control encompasses heterogeneous clinical presentations. The relationship between patterns of asthma symptoms and objective measurements is poorly defined in paediatric asthma. This study includes 115 asthmatic schoolchildren, of which 31 were at inclusion defined as Problematic severe asthma because of inadequate asthma control in the presence of high-dose inhaled corticosteroid (HD-ICS) treatment and at least one other asthma controller drug.