Publications by authors named "Christine Poitou-Bernert"
This article aims to provide guidance on prevention and treatment of COVID-19 in patients with genetic obesity. Key principals of the management of patients with genetic obesity during COVID-19 pandemic for patients that have contracted COVID-19 are to be aware of: possible adrenal insufficiency (e.g.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to evaluate malnutrition in hospitalized COVID-19 patients and its correlation with disease severity and clinical outcomes like ICU transfer or death.
- Among 114 patients studied, a significant 42.1% were found to be malnourished, with an even higher rate of 66.7% in those coming from the ICU.
- Lower levels of albumin were linked to an increased risk of ICU transfer, indicating a crucial need for early nutritional assessments in COVID-19 patients to improve management.
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinitis pigmentosa, obesity, polydactyly, cognitive impairment and renal failure. Pathogenic variants in 24 genes account for the molecular basis of >80% of cases. Toward saturated discovery of the mutational basis of the disorder, we carefully explored our cohorts and identified a hominid-specific SINE-R/VNTR/Alu type F (SVA-F) insertion in exon 13 of BBS1 in eight families.
View Article and Find Full Text PDFBackground: In the last 20 years, substantial improvements have been made in the diagnosis, treatment and management of patients with Prader-Willi syndrome (PWS). Few data on causes of death are available since those improvements were made. Our study assessed the causes of death among French patients with PWS over the first 11 years of experience of the nationwide French Reference Center for PWS (FRC-PWS).
View Article and Find Full Text PDFObjective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese individuals with complete POMC deficiency. While POMC deficiency is very rare, 1-5% of severely obese individuals harbor heterozygous mutations in MC4R.
View Article and Find Full Text PDFThe management of an obese patient involves a multidisciplinary team. The psychological dimension often plays an important role in weight gain and must be taken into account early on in the care pathway. The support given to the patient must notably involve work on body image and how this changes as a result of bariatric surgery.
View Article and Find Full Text PDFBackground: Physical activity has been shown to increase following obesity surgery; however, changes in sedentary behavior in this setting are not known. Our aim was to describe changes in both physical activity and sedentary behavior of obese patients after gastric bypass (GBP) and their relationships with changes in body composition.
Methods: Physical activity, time spent watching TV as typical sedentary behavior (self-report), and body composition (DXA) were assessed before and 6 and 12 months after GBP in 86 obese patients (67 women, 24-66 years old, BMI 41.