The relationship between alcohol consumption and amygdala volume in a community-based sample.

Most prior studies have reported decreased amygdala volume in those with a history of alcohol use disorder. Decreased amygdala volume associated with alcohol use disorder may be related to an increased risk of addiction and relapse. However, the relationship between amygdala volume and a broad range of alcohol consumption is largely unexplored.

Using mathematical modeling to estimate time-independent cancer chemotherapy efficacy parameters.

One of the primary cancer treatment modalities is chemotherapy. Unfortunately, traditional anti-cancer drugs are often not selective and cause damage to healthy cells, leading to serious side effects for patients. For this reason more targeted therapeutics and drug delivery methods are being developed.

Effects of Doxorubicin Delivery by Nitrogen-Doped Graphene Quantum Dots on Cancer Cell Growth: Experimental Study and Mathematical Modeling.

With 18 million new cases diagnosed each year worldwide, cancer strongly impacts both science and society. Current models of cancer cell growth and therapeutic efficacy in vitro are time-dependent and often do not consider the value (the maximum reduction in the growth rate), leading to inconsistencies in the obtained (concentration of the drug at half maximum effect). In this work, we introduce a new dual experimental/modeling approach to model HeLa and MCF-7 cancer cell growth and assess the efficacy of doxorubicin chemotherapeutics, whether alone or delivered by novel nitrogen-doped graphene quantum dots (N-GQDs).

Graphene Oxide as a Multifunctional Platform for Intracellular Delivery, Imaging, and Cancer Sensing.

Graphene oxide (GO), the most common derivative of graphene, is an exceptional nanomaterial that possesses multiple physical properties critical for biomedical applications. GO exhibits pH-dependent fluorescence emission in the visible/near-infrared, providing a possibility of molecular imaging and pH-sensing. It is also water soluble and has a substantial platform for functionalization, allowing for the delivery of multiple therapeutics.

Modulating Chirality-Selective Photoluminescence of Single-Walled Carbon Nanotubes by Ionic Liquids.

The chirality-selective near-infrared emission of surfactant-stabilized single-wall carbon nanotubes could be controlled by simply varying the anion of the commonly used 1-butyl-3-methylimidazolium ionic liquids. This result advances the notion of the designer solvent ability of ionic liquids and provides opportunities for modulating the properties of nanomaterials.