Heart failure from ATTRwt amyloid cardiomyopathy is associated with poor prognosis.

Aims: Amyloid cardiomyopathy is an underappreciated cause of morbidity and mortality. Recent evidence suggests that ATTR wild-type cardiomyopathy (ATTRwt-CM) is probably much more common than widely appreciated. So far, no data are available on comparison of mortality from ATTRwt-CM and other heart failure aetiologies.

Liver dysfunction in chronic heart failure: prevalence, characteristics and prognostic significance.

Background: Although abnormal liver morphology and function have long been recognized, characterization and importance of liver dysfunction in heart failure are poorly defined. This study sought to investigate the relevance of circulating liver function tests (LFTs) in an unselected chronic heart failure (CHF) cohort.

Materials And Methods: A total of 1032 consecutive ambulatory patients with CHF were enrolled from 2000 to 2008.

γ-Glutamyltransferase rather than total bilirubin predicts outcome in chronic heart failure.

Background: Gamma-glutamyltransferase (GGT) and total bilirubin (T-Bil) are elevated and of prognostic significance in chronic heart failure (CHF). This study sought to compare these novel cardiovascular risk markers in CHF.

Methods And Results: We evaluated 1,087 ambulatory patients from our heart failure program.