Improving Outcomes for Women With Metastatic HER-Positive and HER-Low Breast Cancer.

At JADPRO Live 2023, presenters discussed recent updates to clinical practice in metastatic HER2-positive metastatic breast cancer. During the session, they reviewed review recent FDA approvals, the clinical relevance of HER2-low status, and evidence-based practices for managing adverse events associated with novel HER2 agents.

Ultra-Thin Ceramic Substrates for Improved Heatsinking for microLEDs.

MicroLEDs provide unrivaled luminance and operating lifetime, which has led to significant activity using devices for display and non-display applications. The small size and high power density of microLEDs, however, causes increased adverse heating effects which can limit performance. A new generation of electrically insulating high thermal conductivity materials, such as alumina, has been proposed to mitigate these thermal effects when used as a substrate as an alternative to glass.

Gender-Affirming Vaginoplasty: A Comparison of Algorithms, Surgical Techniques and Management Practices across 17 High-volume Centers in North America and Europe.

Unlabelled: Penile inversion vaginoplasty is the most common gender-affirming genital surgery performed around the world. Although individual centers have published their experiences, expert consensus is generally lacking.

Methods: Semistructured interviews were performed with 17 experienced gender surgeons representing a diverse mix of specialties, experience, and countries regarding their patient selection, preoperative management, vaginoplasty techniques, complication management, and postoperative protocols.

A Dense Conformal Electrode Array for High Spatial Resolution Stimulation of Electrosensory Systems.

Studies of electrosensory systems have led to insights into to a number of general issues in biology. However, investigations of these systems have been limited by the inability to precisely control spatial patterns of electrosensory input. In this paper, an electrode array and a system to selectively stimulate spatially restricted regions of an electroreceptor array is presented.

Magnetic and dielectric property control in the multivalent nanoscale perovskite EuBaTiO.

We report nanoscale EuBaTiO, a multiferroic in the bulk and candidate in the search to quantify the electric dipole moment of the electron. EuBaTiO, in the form of nanoparticles and other nanostructures is interesting for nanocomposite integration, biomedical imaging and fundamental research, based upon the prospect of polarizability, f-orbital magnetism and tunable optical/radio luminescence. We developed a [non-hydrolytic]sol-[HO-activated]gel route, derived from in-house metallic Ba/Eu alkoxide precursors and Ti{(OCH(CH)}.

Review of Gravimetric Sensing of Volatile Organic Compounds.

Volatile organic compounds (VOCs) are pervasive in the environment. Since the early 1980s, substantial work has examined the detection of these materials, as they can indicate environmental changes that can affect human health. VOCs and similar compounds present a very specific sensing problem in that they are not reactive and often nonpolar, so it is difficult to find materials that selectively bind or adsorb them.

Solution-Processable Superatomic Thin-Films.

Atomically precise nanoscale clusters could assemble into crystalline ionic crystals akin to the atomic ionic solids through the strong electrostatic interactions between the constituent clusters. Here we show that, unlike atomic ionic solids, the electrostatic interactions between nanoscale clusters could be frustrated by using large clusters with long and flexible side-chains so that the ionic cluster pairs do not crystallize. As such, we report ionic superatomic materials that can be easily solution-processed into completely amorphous and homogeneous thin-films.

Raspberry-like metamolecules exhibiting strong magnetic resonances.

We report a synthetic approach to produce raspberry-like plasmonic nanostructures with unusually strong magnetic resonances, termed raspberry-like metamolecules (raspberry-MMs). The synthesis based on the surfactant-assisted templated seed-growth method allows for the simultaneous one-step synthesis and assembly of well-insulated gold nanoparticles. The aromatic surfactant used for the syntheses forms a thin protective layer around the nanoparticles, preventing them from touching each other and making it possible to pack discrete nanoparticles at close distances in a single cluster.

Planar anchoring strength and pitch measurements in achiral and chiral chromonic liquid crystals using 90-degree twist cells.

Chromonic liquid crystals are formed by molecules that spontaneously assemble into anisotropic structures in water. The ordering unit is therefore a molecular assembly instead of a molecule as in thermotropic liquid crystals. Although it has been known for a long time that certain dyes, drugs, and nucleic acids form chromonic liquid crystals, only recently has enough knowledge been gained on how to control their alignment so that studies of their fundamental liquid crystal properties can be performed.