Comparison of Posttransplant Dermatologic Diseases by Race.

Importance: The risk for skin cancer has been well characterized in white organ transplant recipients (OTRs); however, most patients on the waiting list for organ transplant in the United States are nonwhite. Little is known about cutaneous disease and skin cancer risk in this OTR population.

Objective: To compare the incidence of cutaneous disease between white and nonwhite OTRs.

Nonmelanoma Skin Cancer in Nonwhite Organ Transplant Recipients.

Importance: Organ transplant recipients have a higher incidence of skin cancer. This risk is magnified over time and with continued exposure to immunosuppression. Skin cancer in nonwhite patients is associated with greater morbidity and mortality owing to diagnosis at a more advanced stage, which suggests that nonwhite organ transplant recipients are at even higher risk.

Indeterminate liver and renal lesions: comparison of computed tomography and magnetic resonance imaging in providing a definitive diagnosis and impact on recommendations for additional imaging.

Purpose: The purpose of this study was to compare computed tomography (CT) and magnetic resonance imaging (MRI) in terms of likelihood of providing a definitive diagnosis (DD) and a recommendation for additional imaging (RAI), when performed to evaluate indeterminate liver and renal lesions detected on ultrasound as well as in terms of impact on imaging costs.

Methods: This retrospective study was Health Insurance Portability an Accountability Act (HIPAA)-compliant and institutional review board-approved, with waiver of informed consent. We identified consecutive indeterminate liver and renal lesions detected on ultrasound that underwent contrast-enhanced CT or MRI for further characterization.

Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.

Functional roles for the cancer cell-associated membrane type I matrix metalloproteinase (MT1-MMP) during early steps of the metastatic cascade in primary tumors remain unresolved. In an effort to determine its significance, we determined the in vivo effects of RNAi-mediated downregulation in mammary cancer cells on the migration, blood and lymphatic vessel invasion (LVI), and lymph node and lung metastasis. We also correlated the expression of cancer cell MT1-MMP with blood vessel invasion (BVI) in 102 breast cancer biopsies.